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Increased serum interleukin-32 levels in patients with Behçet's disease
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2019-03-15T02:32:41Z | - |
dc.date.available | 2019-03-15T02:32:41Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167567 | - |
dc.description.abstract | AIM: Interleukin (IL)-32 is known to act as a proinflammatory cytokine and is likely involved in several chronic inflammatory diseases. The aims of this study were to investigate whether serum IL-32 levels are elevated in patients with Behçet's disease (BD) and to identify the correlation between IL-32 levels and disease activity. METHODS: We enrolled 50 patients with BD and 35 healthy controls. Serum IL-32 levels were measured using an enzyme-linked immunosorbent assay. Serum levels of IL-12p70, IL-17A, IL-1β, IL-6 and IL-8 were measured using a multiplex assay. BD disease activity was determined using the Behçet's Disease Current Activity Form (BDCAF). RESULTS: Serum IL-32 levels were significantly higher in patients with BD (median [interquartile ranges], 0.4 [0.1-736.2] pg/mL) than in healthy controls (0.1 [0.1-14.7] pg/mL, P = 0.041). When patients with BD were divided into active (patient index score ≥ 2 or transformed index score ≥ 5 in the BDCAF) and inactive groups, IL-32 levels tended to be higher in patients with active BD, although this observation was statistically insignificant. Serum levels of IL-12p70, IL-17A, IL-1β, IL-6 and IL-8 did not differ between active and inactive groups. There was a weak positive correlation between serum IL-32 levels and BDCAF scores (R = 0.301, P = 0.033). BD patients with recent arthralgia exhibited higher IL-32 levels than did those without (P < 0.001). CONCLUSION: These findings suggest that IL-32 may play a minor role in the pathogenesis of BD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley on behalf of the Asia Pacific League of Associations for Rheumatology | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Increased serum interleukin-32 levels in patients with Behçet's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | You‐Jung Ha | - |
dc.contributor.googleauthor | Jin‐Su Park | - |
dc.contributor.googleauthor | Mi‐il Kang | - |
dc.contributor.googleauthor | Soo‐Kon Lee | - |
dc.contributor.googleauthor | Yong‐Beom Park | - |
dc.contributor.googleauthor | Sang‐Won Lee | - |
dc.identifier.doi | 10.1111/1756-185X.13072 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J01158 | - |
dc.identifier.eissn | 1756-185X | - |
dc.identifier.pmid | 28378461 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/1756-185X.13072 | - |
dc.subject.keyword | Behçet's disease | - |
dc.subject.keyword | arthralgia | - |
dc.subject.keyword | cytokines | - |
dc.subject.keyword | interleukin-32 | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2167 | - |
dc.citation.endPage | 2174 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.21(12) : 2167-2174, 2018 | - |
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