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Serine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells.

DC Field Value Language
dc.contributor.author박수연-
dc.contributor.author유정윤-
dc.contributor.author윤호근-
dc.contributor.author이승현-
dc.date.accessioned2019-03-15T02:32:04Z-
dc.date.available2019-03-15T02:32:04Z-
dc.date.issued2019-
dc.identifier.issn0021-9541-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167562-
dc.description.abstractAlthough programed cell death 5 (PDCD5) is an important protein in p53-mediated proapoptotic signaling, very little is known about PDCD5-related cell death. In this study, we report that serine/threonine kinase 31 (STK31) interacts with PDCD5, which maintains the stability of PDCD5. STK31 overexpression significantly activated PDCD5 stabilization and p53-mediated apoptosis in response to etoposide (ET). However, STK31 knockdown did not enhance apoptosis by ET treatment. Moreover, when STK31 was depleted, PDCD5 inhibited the activation of the p53 signaling pathway with ET, indicating that the PDCD5-STK31 network has an essential role in p53 activation. Importantly, STK31 activated the p53 signaling pathway by genotoxic stress through positive regulation of PDCD5-mediated apoptosis. We thus demonstrated that overexpression of STK31 greatly inhibited tumorigenic growth and increased the chemosensitivity of HCT116 human colorectal carcinoma cells. Taken together, these findings demonstrate that the STK31-PDCD5 complex network regulates apoptosis of cancer cells, and STK31 is a positive apoptosis regulator that inhibits tumorigenesis of colon cancer cells by inducing PDCD5-mediated apoptosis in response to genotoxic stress.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJOURNAL OF CELLULAR PHYSIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSerine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorSungmin Kwak-
dc.contributor.googleauthorSeung‐Hyun Lee-
dc.contributor.googleauthorEun‐Jung Han-
dc.contributor.googleauthorSoo‐Yeon Park-
dc.contributor.googleauthorMi‐Hyeon Jeong-
dc.contributor.googleauthorJaesung Seo-
dc.contributor.googleauthorSeung‐Ho Park-
dc.contributor.googleauthorGi‐Jun Sung-
dc.contributor.googleauthorJung‐Yoon Yoo-
dc.contributor.googleauthorHo‐Geun Yoon-
dc.contributor.googleauthorKyung‐Chul Choi-
dc.identifier.doi10.1002/jcp.27079-
dc.contributor.localIdA01534-
dc.contributor.localIdA02502-
dc.contributor.localIdA02625-
dc.contributor.localIdA02932-
dc.relation.journalcodeJ01304-
dc.identifier.eissn1097-4652-
dc.identifier.pmid30144069-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/jcp.27079-
dc.subject.keywordPDCD5-
dc.subject.keywordSTK31-
dc.subject.keywordapoptosis-
dc.subject.keywordcolon cancer-
dc.subject.keywordp53-
dc.contributor.alternativeNamePark, Soo Yeon-
dc.contributor.affiliatedAuthor박수연-
dc.contributor.affiliatedAuthor유정윤-
dc.contributor.affiliatedAuthor윤호근-
dc.contributor.affiliatedAuthor이승현-
dc.citation.volume234-
dc.citation.number3-
dc.citation.startPage2649-
dc.citation.endPage2658-
dc.identifier.bibliographicCitationJOURNAL OF CELLULAR PHYSIOLOGY, Vol.234(3) : 2649-2658, 2019-
dc.identifier.rimsid61750-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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