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(18)F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia

Authors
 Hanna Cho  ;  Hee Jin Kim  ;  Jae Yong Choi  ;  Young Hoon Ryu  ;  Myung Sik Lee  ;  Duk L. Na  ;  Sang Won Seo  ;  Chul Hyoung Lyoo 
Citation
 Neurobiology of Aging, Vol.75 : 187-197, 2019 
Journal Title
 Neurobiology of Aging 
ISSN
 0197-4580 
Issue Date
2019
Keywords
(18)F-flortaucipir ; Positron emission tomography ; Primary progressive aphasia ; Tau
Abstract
We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. 18F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)- subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ- and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. 18F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased 18F-flortaucipir uptake. 18F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458018304196
DOI
10.1016/j.neurobiolaging.2018.11.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
류철형(Lyoo, Chul Hyoung) ORCID logo https://orcid.org/0000-0003-2231-672X
유영훈(Ryu, Young Hoon) ORCID logo https://orcid.org/0000-0002-9000-5563
이명식(Lee, Myung Sik) ORCID logo https://orcid.org/0000-0002-8413-1854
조한나(Cho, Hanna) ORCID logo https://orcid.org/0000-0001-5936-1546
최재용(Choi, Jae Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167554
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