Cited 7 times in
Patterns of failures after surgical resection in olfactory neuroblastoma
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 김의현 | - |
dc.contributor.author | 김창훈 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 이규성 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 김나리 | - |
dc.date.accessioned | 2019-03-15T02:25:13Z | - |
dc.date.available | 2019-03-15T02:25:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167464 | - |
dc.description.abstract | INTRODUCTION: Patterns of failure in patients with olfactory neuroblastoma (ONB) according to two surgical approaches, craniofacial resection (CFR) and endoscopic surgery (ENDO), have yet to be analyzed. METHODS: We retrospectively reviewed 28 patients with surgically treated ONB between January 1995 and October 2017. Fourteen (50.0%) patients underwent CFR (9 CFR alone, 5 ENDO-assisted CFR) and 14 (50.0%) underwent ENDO. Nineteen (67.9%) patients underwent post-operative radiotherapy (RT). RESULTS: At a median follow-up of 53.8 months (range 10.4-195.3), the 5-year progression-free survival (PFS) and 10-year overall survival were 37.3% and 57.5%, respectively. Patients with adjuvant RT had a 5-year PFS of 46.7%, whereas those treated with surgery alone had a 5-year PFS of 19.4% (p = 0.01). Locoregional failure (LRF) occurred in ten patients (median 59.6 months after initial diagnosis; range 12.7-59.7). Neck node metastasis occurred in 25.0% (7 of 28). Five patients with ENDO showed LRF and underwent proper subsequent treatments with either surgery or adjuvant RT. Approximately 35.7% patients (five patients) in the CFR group experienced distant metastasis in the intracranial dura region (median 116.4 months after initial diagnosis; range 2.6-142.4). Three of four patients who developed LRF after CFR developed dura-based metastasis. CONCLUSIONS: Both dura-based and neck node metastasis in the delayed phase were distinct patterns of failure in ONB. Patterns of recurrence differed based on surgical approach; dura-based metastases were common after CFR. LRF was the distinct failure pattern in ENDO, but could be successfully salvaged. Treatment outcome was improved considerably with RT following surgical resection. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | JOURNAL OF NEURO-ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Patterns of failures after surgical resection in olfactory neuroblastoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Nalee Kim | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.contributor.googleauthor | Eui Hyun Kim | - |
dc.contributor.googleauthor | Chang-Hoon Kim | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Kyu-Sung Lee | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.identifier.doi | 10.1007/s11060-018-03056-0 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00837 | - |
dc.contributor.localId | A01050 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A02682 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A03470 | - |
dc.relation.journalcode | J01629 | - |
dc.identifier.eissn | 1573-7373 | - |
dc.identifier.pmid | 30506150 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs11060-018-03056-0 | - |
dc.subject.keyword | Craniofacial resection | - |
dc.subject.keyword | Endoscopy | - |
dc.subject.keyword | Head and neck cancer | - |
dc.subject.keyword | Olfactory neuroblastoma | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | 금기창 | - |
dc.contributor.affiliatedAuthor | 김의현 | - |
dc.contributor.affiliatedAuthor | 김창훈 | - |
dc.contributor.affiliatedAuthor | 서창옥 | - |
dc.contributor.affiliatedAuthor | 이규성 | - |
dc.contributor.affiliatedAuthor | 이창걸 | - |
dc.contributor.affiliatedAuthor | 장종희 | - |
dc.citation.volume | 141 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 459 | - |
dc.citation.endPage | 466 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, Vol.141(2) : 459-466, 2019 | - |
dc.identifier.rimsid | 48803 | - |
dc.type.rims | ART | - |
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