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Expression of glutamine metabolism-related proteins in Hürthle cell neoplasm of thyroid: Comparison with follicular neoplasm
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2019-03-15T02:24:54Z | - |
dc.date.available | 2019-03-15T02:24:54Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167451 | - |
dc.description.abstract | PURPOSE: We evaluated the expression of glutaminolysis-related proteins in Hurthle cell neoplasms (HCN) and follicular neoplasms (FN) of the thyroid, and investigated its clinical implication. METHODS: Tissue microarrays were constructed from 264 FNs (112 follicular carcinomas [FCs] and 152 follicular adenomas [FAs]) and 108 HCNs (27 Hurthle cell carcinomas [HCCs] and 81 Hurthle cell adenomas [HCAs]. The immunohistochemical staining result of 3 glutaminolysis-related proteins (Glutaminase 1 [GLS1], glutaminate dehydrogenase [GDH] and alanine- serine, cysteine-preferring transporter 2 [ASCT2]) was analyzed. RESULTS: GLS1 and GDH showed significantly higher expression rates in HCN compared to FN (P<0.001). More HCN cases showed co-positivity of multiple glutaminolysis-related proteins than those of FN cases (P<0.001). In silico analysis, both GLUD1 and GLUD2 showed higher expression rate in HCA compared to FA (P=0.027 and P=0.018, respectively). SLC1A5 expression was highest in HCA, followed by FC and FA (HCA vs FC, P=0.023; FC vs FA, P=0.002). CONCLUSION: FN and HCN exhibit a different expression pattern for glutaminolysis-related proteins, and GLS1 and GDH have higher expression rates in HCN and FN. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Histology and Histopathology | - |
dc.relation.isPartOf | HISTOLOGY AND HISTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression of glutamine metabolism-related proteins in Hürthle cell neoplasm of thyroid: Comparison with follicular neoplasm | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Haerin Jang | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.14670/HH-18-036 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J00993 | - |
dc.identifier.eissn | 1699-5848 | - |
dc.identifier.pmid | 30191947 | - |
dc.identifier.url | http://www.hh.um.es/Abstracts/Vol_34/34_2/34_2_167.htm | - |
dc.subject.keyword | Metabolism | - |
dc.subject.keyword | Glutamine | - |
dc.subject.keyword | Hurthle cell | - |
dc.subject.keyword | Thyroid | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 167 | - |
dc.citation.endPage | 174 | - |
dc.identifier.bibliographicCitation | HISTOLOGY AND HISTOPATHOLOGY, Vol.34(2) : 167-174, 2019 | - |
dc.identifier.rimsid | 48798 | - |
dc.type.rims | ART | - |
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