Cited 10 times in
Does p16+ Predict a Favorable Prognosis for Oropharyngeal Cancer? Risk Factors for Treatment Failure for Patients Who Underwent Surgery-Based Therapy
DC Field | Value | Language |
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dc.contributor.author | 고윤우 | - |
dc.contributor.author | 김세헌 | - |
dc.contributor.author | 박영민 | - |
dc.contributor.author | 최은창 | - |
dc.date.accessioned | 2019-03-15T02:24:40Z | - |
dc.date.available | 2019-03-15T02:24:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167447 | - |
dc.description.abstract | BACKGROUND: This study aimed to identify prognostic clinicopathologic factors that could predict treatment failure and to analyze clinical data from p16+ oropharyngeal squamous cell carcinoma (OPSCC) patients who underwent surgery. METHODS: Data from p16+ OPSCC patients who underwent surgery at Severance Hospital of Yonsei University were retrospectively reviewed. RESULTS: The average smoking history was 14.6 pack-years (range 0-94 pack-years). Of the 188 patients, 73 (38.8%) underwent transoral robotic surgery (TORS) for surgical treatment of their primary lesions, and the remaining 115 patients (61.2%) underwent conventional surgery. Extracapsular nodal spread was detected in 87 patients (46.3%). At histologic examination, 67 patients (35.6%) showed positive surgical margins, and 121 patients (64.4%) had negative surgical margins. Postoperative adjuvant treatment was performed for 167 patients (88.8%). During the follow-up period, there were 18 recurrences including 2 local recurrences, 10 regional recurrences, and 6 distant metastases. During the study period, 17 deaths occurred. The univariate analysis showed that the American Joint Committee on Cancer (AJCC) 8th-edition staging system, lymphovascular invasion, more than four metastatic lymph nodes, and a smoking history of more than 10 pack-years were significantly associated with treatment failure. In the multivariate analysis, only the AJCC 8th-edition staging system was significantly associated with the patient's survival. CONCLUSION: Surgical treatment methods including TORS for p16+ OPSCC patients showed excellent oncologic results, and many previously known clinicopathologic factors did not show a significant relationship with patient prognosis. Only the newly revised AJCC 8th-edition staging system showed a significant relationship with patient survival, and this should be considered in the setting of p16+ OPSCC treatment guidelines in the future. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Does p16+ Predict a Favorable Prognosis for Oropharyngeal Cancer? Risk Factors for Treatment Failure for Patients Who Underwent Surgery-Based Therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Young Min Park | - |
dc.contributor.googleauthor | Min Seok Kang | - |
dc.contributor.googleauthor | Yoon Woo Koh | - |
dc.contributor.googleauthor | Eun Chang Choi | - |
dc.contributor.googleauthor | Se-Heon Kim | - |
dc.identifier.doi | 10.1245/s10434-018-6806-x | - |
dc.contributor.localId | A00133 | - |
dc.contributor.localId | A00605 | - |
dc.contributor.localId | A01566 | - |
dc.contributor.localId | A04161 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 30276645 | - |
dc.identifier.url | https://link.springer.com/article/10.1245%2Fs10434-018-6806-x | - |
dc.contributor.alternativeName | Kho, Yoon Woo | - |
dc.contributor.affiliatedAuthor | 고윤우 | - |
dc.contributor.affiliatedAuthor | 김세헌 | - |
dc.contributor.affiliatedAuthor | 박영민 | - |
dc.contributor.affiliatedAuthor | 최은창 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 547 | - |
dc.citation.endPage | 554 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.26(2) : 547-554, 2019 | - |
dc.identifier.rimsid | 48794 | - |
dc.type.rims | ART | - |
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