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Rufinamide efficacy and safety in children aged 1-4 years with Lennox-Gastaut syndrome

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dc.contributor.author강훈철-
dc.contributor.author김흥동-
dc.contributor.author이준수-
dc.date.accessioned2019-03-15T02:24:24Z-
dc.date.available2019-03-15T02:24:24Z-
dc.date.issued2018-
dc.identifier.issn0387-7604-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167442-
dc.description.abstractPURPOSE: The treatment options for Lennox-Gastaut syndrome (LGS), a pediatric epileptic syndrome, are limited, especially in younger children. Rufinamide tablets were safe and effective as an add-on treatment in Korean children and adolescents <20 years of age with LGS. This subgroup analysis aimed to evaluate the efficacy and safety of rufinamide tablets in LGS pediatric patients aged 1-4 years. METHODS: This was a retrospective, observational study in LGS patients aged 1-4 years who received 12 weeks of treatment with rufinamide orally as an adjuvant treatment between April and June 2010. The proportion of responders (patients with a ≥50% reduction in seizure frequency after rufinamide treatment) was evaluated according to the type of seizure. The proportion of patients who were seizure-free was also evaluated. Adverse events (AEs) were evaluated after 12 weeks of treatment. RESULTS: Among the 15 patients evaluated, one discontinued treatment because of worsening seizures 4 weeks after administration of rufinamide. Seven (46.67%) patients were responders and four patients were seizure-free. There were four responders with convulsive seizures, one each for myoclonic seizures and drop attacks, and spasms. The responder rate was increased to 69.23% by long-term treatment of rufinamide. AEs were experienced by three patients. One patient each experienced somnolence, fatigue, and rash. CONCLUSION: Rufinamide tablets were efficacious and well tolerated in LGS patients aged 1-4 years, at doses up to 1000 mg per day, when given as add-on therapy to other antiepileptic drugs.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfBRAIN & DEVELOPMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdjuvants, Pharmaceutic-
dc.subject.MESHAnticonvulsants/administration & dosage-
dc.subject.MESHAnticonvulsants/adverse effects-
dc.subject.MESHAnticonvulsants/pharmacology*-
dc.subject.MESHChild, Preschool-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHLennox Gastaut Syndrome/drug therapy*-
dc.subject.MESHMale-
dc.subject.MESHOutcome Assessment (Health Care)*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTriazoles/administration & dosage-
dc.subject.MESHTriazoles/adverse effects-
dc.subject.MESHTriazoles/pharmacology*-
dc.titleRufinamide efficacy and safety in children aged 1-4 years with Lennox-Gastaut syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorShin Hye Kim-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorHeung Dong Kim-
dc.identifier.doi10.1016/j.braindev.2018.07.020-
dc.contributor.localIdA00102-
dc.contributor.localIdA01208-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ00386-
dc.identifier.eissn1872-7131-
dc.identifier.pmid30166208-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S038776041830384X-
dc.subject.keywordEfficacy-
dc.subject.keywordLennox–Gastaut syndrome-
dc.subject.keywordPediatric-
dc.subject.keywordRufinamide-
dc.subject.keywordSafety-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.affiliatedAuthor강훈철-
dc.contributor.affiliatedAuthor김흥동-
dc.contributor.affiliatedAuthor이준수-
dc.citation.volume40-
dc.citation.number10-
dc.citation.startPage897-
dc.citation.endPage903-
dc.identifier.bibliographicCitationBRAIN & DEVELOPMENT, Vol.40(10) : 897-903, 2018-
dc.identifier.rimsid48789-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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