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Teneligliptin versus sitagliptin in Korean patients with type 2 diabetes inadequately controlled with metformin and glimepiride: A randomized, double-blind, non-inferiority trial

DC FieldValueLanguage
dc.contributor.author강은석-
dc.date.accessioned2019-03-15T02:24:07Z-
dc.date.available2019-03-15T02:24:07Z-
dc.date.issued2019-
dc.identifier.issn1462-8902-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167437-
dc.description.abstractAIM: To assess the efficacy and safety of add-on therapy with the dipeptidyl peptidase-4 inhibitor teneligliptin compared with sitagliptin in patients with type 2 diabetes (T2DM) inadequately controlled with metformin and glimepiride. MATERIALS AND METHODS: This was a phase 3, randomized, double-blind, non-inferiority study of adult Korean subjects with T2DM (n = 201), with HbA1c ranging from 7.0% to 11.0%, on stable doses of metformin plus glimepiride. Subjects were randomized in a 1:1 fashion to receive either oral teneligliptin 20 mg or sitagliptin 100 mg for 24 weeks. The primary endpoint was change from baseline in HbA1c. RESULTS: At baseline, mean age was 60.56 ± 9.41 years, body mass index was 25.23 ± 2.85 kg/m2 and HbA1c was 8.11% ± 0.79%. At 24 weeks, both groups achieved significant reductions from baseline in HbA1c (teneligliptin, -1.03% ± 0.10% [P < 0.0001]; sitagliptin, -1.02% ± 0.10% [P < 0.0001]). The inter-group difference was -0.01% (95% confidence interval [CI]: -0.28, 0.26; P = 0.9497); the upper limit of the 95% CI was within the preset limit for non-inferiority (0.4%). There were no significant differences between groups in the proportion of patients achieving HbA1c targets, or changes from baseline in fasting plasma glucose, body weight or lipid levels at 24 weeks. Rates of adverse events (teneligliptin, n = 63 [61.76%]; sitagliptin, n = 61 [62.24%]; P = 0.9442) and hypoglycaemia (teneligliptin, n = 32 [31.37%]; sitagliptin, n = 28 [28.57%]; P = 0.6656) were similar. CONCLUSION: Teneligliptin was non-inferior to sitagliptin in the context of triple therapy for T2DM and is an important option in this setting.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfDiabetes Obesity & Metabolism-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTeneligliptin versus sitagliptin in Korean patients with type 2 diabetes inadequately controlled with metformin and glimepiride: A randomized, double-blind, non-inferiority trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYonghyun Kim-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorHak Chul Jang-
dc.contributor.googleauthorDong Jun Kim-
dc.contributor.googleauthorTaekeun Oh-
dc.contributor.googleauthorEun Sook Kim-
dc.contributor.googleauthorNan‐Hee Kim-
dc.contributor.googleauthorKyung Mook Choi-
dc.contributor.googleauthorSung‐Rae Kim-
dc.contributor.googleauthorJiYoung You-
dc.contributor.googleauthorSe‐Jin Kim-
dc.contributor.googleauthorMoon‐Kyu Lee-
dc.identifier.doi10.1111/dom.13566-
dc.contributor.localIdA00068-
dc.relation.journalcodeJ00722-
dc.identifier.eissn1463-1326-
dc.identifier.pmid30362280-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/dom.13566-
dc.subject.keywordDPP-4 inhibitor-
dc.subject.keywordsitagliptin-
dc.subject.keywordteneligliptin-
dc.subject.keywordtriple therapy-
dc.subject.keywordtype 2 diabetes-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.affiliatedAuthor강은석-
dc.citation.volume21-
dc.citation.number3-
dc.citation.startPage631-
dc.citation.endPage639-
dc.identifier.bibliographicCitationDiabetes Obesity & Metabolism, Vol.21(3) : 631-639, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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