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Therapeutic Efficacy of Exclusive Enteral Nutrition with Specific Polymeric Diet in Pediatric Crohn's Disease
DC Field | Value | Language |
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dc.contributor.author | 강윤구 | - |
dc.contributor.author | 김승 | - |
dc.contributor.author | 박소원 | - |
dc.date.accessioned | 2019-03-15T02:24:03Z | - |
dc.date.available | 2019-03-15T02:24:03Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2234-8646 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167436 | - |
dc.description.abstract | Purpose: The efficacy of exclusive enteral nutrition (EEN) with a polymeric diet has not been confirmed in Korean pediatric patients with Crohn's disease (CD). This study aimed to compare the effectiveness of EEN with a specific polymeric diet (Encover®) and corticosteroids (CSs) for the induction of remission in Korean pediatric CD patients. Methods: We retrospectively compared data from 51 pediatric CD patients who underwent induction therapy with EEN (n=19) or CSs (n=32) at Severance Children's Hospital or Incheon St. Mary's Hospital in Korea. The primary endpoint of this study was the rate of clinical remission, defined as a Pediatric Crohn's Disease Activity Index (PCDAI) score <10, after 8 weeks of induction treatment. Clinical, laboratory, and growth data at post-induction as well as their changes from baseline were also compared between groups. Results: After 8 weeks of induction therapy, clinical remission rates were 78.9% (15/19) and 65.6% (21/32) in the EEN and CS groups, respectively (p=0.313). No significant differences in PCDAI scores, laboratory variables, and growth parameters were noted between the two groups at post-induction. However, significant changes in albumin levels at post-induction were observed in the EEN group compared to the CS group (p=0.038). Conclusion: Our results suggest that the effectiveness of EEN with a polymeric diet and CSs for induction therapy did not differ in Korean pediatric CD patients. EEN with a polymeric diet is a good first-line treatment option for the induction of remission in these patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition | - |
dc.relation.isPartOf | PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Therapeutic Efficacy of Exclusive Enteral Nutrition with Specific Polymeric Diet in Pediatric Crohn's Disease | - |
dc.title.alternative | . | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Yunkoo Kang | - |
dc.contributor.googleauthor | Sowon Park | - |
dc.contributor.googleauthor | Seung Kim | - |
dc.contributor.googleauthor | Sang Yong Kim | - |
dc.contributor.googleauthor | Hong Koh | - |
dc.identifier.doi | 10.5223/pghn.2019.22.1.72 | - |
dc.contributor.localId | A05213 | - |
dc.contributor.localId | A00651 | - |
dc.contributor.localId | A05216 | - |
dc.relation.journalcode | J02485 | - |
dc.identifier.eissn | 2234-8840 | - |
dc.identifier.pmid | 30671376 | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Crohn disease | - |
dc.subject.keyword | Enteral nutrition | - |
dc.contributor.alternativeName | Kang, Yunkoo | - |
dc.contributor.affiliatedAuthor | 강윤구 | - |
dc.contributor.affiliatedAuthor | 김승 | - |
dc.contributor.affiliatedAuthor | 박소원 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 72 | - |
dc.citation.endPage | 79 | - |
dc.identifier.bibliographicCitation | PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION, Vol.22(1) : 72-79, 2019 | - |
dc.identifier.rimsid | 47595 | - |
dc.type.rims | ART | - |
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