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Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity

Authors
 Hyang Joo Ryu  ;  Eun Kyung Kim  ;  Byoung Chul Cho  ;  Sun Och Yoon 
Citation
 Head & Neck, Vol.41(1) : 198-207, 2019 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2019
Keywords
cancer immunity ; head and neck ; molecular markers ; squamous cell carcinoma ; young age
Abstract
BACKGROUND: The purpose of this study was to comprehensively characterize head and neck squamous cell carcinoma (HNSCC) arising in young patients (<45 years old). METHODS: We performed immunohistochemistry, silver, and fluorescence in situ hybridization using samples obtained from 396 radically resected cases among 1787 HNSCCs. RESULTS: Young age HNSCCs occurred in 10.9% (194/1787) and were most common in the oral tongue (50.5%). They revealed distinctively lower frequency of p16 positivity, high c-MET expression, MET copy number gain, and lower pan-Trk expression. PD-L1 positivity in tumor cells and ICOS+ tumor infiltrating lymphocytes (TILs) were higher in the young age. Perineural invasion, PD-L1 positivity, and higher ratio of CD163+ tumor infiltrating macrophages to CD8 + TILs were determined to be independent factors for poor progression-free survival. CONCLUSION: Characterizing these features of young age HNSCC may help to identify the underlying pathogenesis and to improve patient outcome through different treatment strategies
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/hed.25507
DOI
10.1002/hed.25507
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김은경(Kim, Eun Kyung)
윤선옥(Yoon, Sun Och) ORCID logo https://orcid.org/0000-0002-5115-1402
조병철(Cho, Byoung Chul) ORCID logo https://orcid.org/0000-0002-5562-270X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167364
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