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The Effect of Hospital Case Volume on Clinical Outcomes in Patients with Nasopharyngeal Carcinoma: A Multi-institutional Retrospective Analysis (KROG-1106)

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dc.contributor.author금기창-
dc.contributor.author이창걸-
dc.date.accessioned2019-02-14T02:02:56Z-
dc.date.available2019-02-14T02:02:56Z-
dc.date.issued2019-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167363-
dc.description.abstractPURPOSE: The purpose of this study was to investigate the effect of hospital case volume on clinical outcomes in patients with nasopharyngeal carcinoma (NPC). Materials and Methods: Data on 1,073 patients with cT1-4N0-3M0 NPC were collected from a multi-institutional retrospective database (KROG 11-06). All patients received definitive radiotherapy (RT) either with three-dimensional-conformal RT (3D-CRT) (n=576) or intensity-modulated RT (IMRT) (n=497). The patients were divided into two groups treated at high volume institution (HVI) (n=750) and low volume institution (LVI) (n=323), defined as patient volume ≥ 10 (median, 13; range, 10 to 18) and < 10 patients per year (median, 3; range, 2 to 6), respectively. Endpoints were overall survival (OS) and loco-regional progression-free survival (LRPFS). RESULTS: At a median follow-up of 56.7 months, the outcomes were significantly better in those treated at HVI than at LVI. For the 614 patients of propensity score-matched cohort, 5-year OS and LRPFS were consistently higher in the HVI group than in the LVI group (OS: 78.4% vs. 62.7%, p < 0.001; LRPFS: 86.2% vs. 65.8%, p < 0.001, respectively). According to RT modality, significant difference in 5-year OS was observed in patients receiving 3D-CRT (78.7% for HVI vs. 58.9% for LVI, p < 0.001) and not in those receiving IMRT (77.3% for HVI vs. 75.5% for LVI, p=0.170). CONCLUSION: A significant relationship was observed between HVI and LVI for the clinical outcomes of patients with NPC. However, the difference in outcome becomes insignificant in the IMRT era, probably due to the standardization of practice by education.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Effect of Hospital Case Volume on Clinical Outcomes in Patients with Nasopharyngeal Carcinoma: A Multi-institutional Retrospective Analysis (KROG-1106)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorBoram Ha-
dc.contributor.googleauthorKwan Ho Cho-
dc.contributor.googleauthorSung Ho Moon-
dc.contributor.googleauthorChang-Geol Lee-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorYeon-Sil Kim-
dc.contributor.googleauthorHong-Gyun Wu-
dc.contributor.googleauthorJin Ho Kim-
dc.contributor.googleauthorYong Chan Ahn-
dc.contributor.googleauthorDongryul Oh-
dc.contributor.googleauthorJae Myoung Noh-
dc.contributor.googleauthorJong Hoon Lee-
dc.contributor.googleauthorSung Hwan Kim-
dc.contributor.googleauthorWon Taek Kim-
dc.contributor.googleauthorYoung-Taek Oh-
dc.contributor.googleauthorMin Kyu Kang-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorJi-Yoon Kim-
dc.contributor.googleauthorMoon-June Cho-
dc.contributor.googleauthorChul Seoung Kay-
dc.contributor.googleauthorJin Hwa Choi-
dc.identifier.doi10.4143/crt.2017.273-
dc.contributor.localIdA00272-
dc.contributor.localIdA03240-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid29397658-
dc.subject.keywordHospital-
dc.subject.keywordIntensity-modulated radiotherapy-
dc.subject.keywordLow- or high-volume-
dc.subject.keywordNasopharyngeal neoplasms-
dc.subject.keywordThree-dimensional conformal radiotherapy-
dc.subject.keywordTreatment outcome-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.affiliatedAuthor금기창-
dc.contributor.affiliatedAuthor이창걸-
dc.citation.volume51-
dc.citation.number1-
dc.citation.startPage12-
dc.citation.endPage23-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.51(1) : 12-23, 2019-
dc.identifier.rimsid61560-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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