Cited 13 times in
Predictors of biochemical recurrence after Retzius-sparing robot-assisted radical prostatectomy: Analysis of 359 cases with a median follow-up period of 26 months
DC Field | Value | Language |
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dc.contributor.author | 나군호 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 한웅규 | - |
dc.contributor.author | 함원식 | - |
dc.date.accessioned | 2019-02-14T01:56:22Z | - |
dc.date.available | 2019-02-14T01:56:22Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0919-8172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167306 | - |
dc.description.abstract | OBJECTIVES: Our aim was to evaluate the predictors of biochemical recurrence after Retzius-sparing robot-assisted radical prostatectomy. METHODS: The study cohort consisted of 359 consecutive non-metastatic prostate cancer patients who underwent Retzius-sparing robot-assisted radical prostatectomy between November 2012 and January 2016. According to the National Comprehensive Cancer Network prostate cancer risk classification, 164 patients (45.7%) had high- or very high-risk prostate cancer. No patient received adjuvant therapy until documented biochemical recurrence. Biochemical recurrence-free survival was estimated using the Kaplan-Meier method. Univariable and multivariable Cox proportional hazards regression models were used to determine variables predictive of biochemical recurrence. RESULTS: The median follow-up period was 26 months (interquartile range 19-38 months). The overall biochemical recurrence rate was 14.8%, and the median time to biochemical recurrence was 11 months (interquartile range 6-22 months). The 3-year biochemical recurrence-free survival probability was 71.2%, 72.1%, 88.7%, 82.3% and 95.7% in very high-, high-, intermediate-, low- and very low-risk prostate cancer, respectively (log-rank, P < 0.001). On multivariable analysis, preoperative prostate-specific antigen (hazard ratio 1.03, 95% confidence interval 1.02-1.04; P < 0.0001), percentage of maximum core involvement on biopsy (hazard ratio 1.02, 95% confidence interval 1.01-1.03; P = 0.029) and clinical stage ≥T3a (hazard ratio 2.12, 95% confidence interval 1.02-4.39; P = 0.043) were predictors of biochemical recurrence, whereas pathological Gleason score ≥8 (hazard ratio 5.63, 95% confidence interval 1.62-19.61; P = 0.007) and pathological tumor volume (hazard ratio 1.08, 95% confidence interval 1.04-1.20; P < 0.001) were the main pathological predictors of biochemical recurrence. CONCLUSIONS: Retzius-sparing robot-assisted radical prostatectomy confers effective biochemical recurrence control at the mid-term follow-up period. Preoperative prostate-specific antigen, advanced clinical stage and higher Gleason score were important predictors of biochemical recurrence after Retzius-sparing robot-assisted radical prostatectomy. Long-term oncological safety still needs to be established. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Science Asia | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Predictors of biochemical recurrence after Retzius-sparing robot-assisted radical prostatectomy: Analysis of 359 cases with a median follow-up period of 26 months | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Ali Abdel Raheem | - |
dc.contributor.googleauthor | Ki Don Chang | - |
dc.contributor.googleauthor | Mohammed Jayed Alenzi | - |
dc.contributor.googleauthor | Won Sik Ham | - |
dc.contributor.googleauthor | Woong Kyu Han | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.identifier.doi | 10.1111/iju.13808 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04308 | - |
dc.contributor.localId | A04337 | - |
dc.relation.journalcode | J01169 | - |
dc.identifier.eissn | 1442-2042 | - |
dc.identifier.pmid | 30276864 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/iju.13808 | - |
dc.subject.keyword | Retzius-sparing | - |
dc.subject.keyword | biochemical recurrence | - |
dc.subject.keyword | prostate cancer | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | 나군호 | - |
dc.contributor.affiliatedAuthor | 최영득 | - |
dc.contributor.affiliatedAuthor | 한웅규 | - |
dc.contributor.affiliatedAuthor | 함원식 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1006 | - |
dc.citation.endPage | 1014 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF UROLOGY, Vol.25(12) : 1006-1014, 2018 | - |
dc.identifier.rimsid | 61508 | - |
dc.type.rims | ART | - |
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