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Radiofrequency ablation vs. surgery for perivascular hepatocellular carcinoma: Propensity score analyses of long-term outcomes

Authors
 Sunyoung Lee  ;  Tae Wook Kang  ;  Dong Ik Cha  ;  Kyoung Doo Song  ;  Min Woo Lee  ;  Hyunchul Rhim  ;  Hyo Keun Lim  ;  Dong Hyun Sinn  ;  Jong Man Kim  ;  Kyunga Kim 
Citation
 JOURNAL OF HEPATOLOGY, Vol.69(1) : 70-78, 2018 
Journal Title
 JOURNAL OF HEPATOLOGY 
ISSN
 0168-8278 
Issue Date
2018
Keywords
Hepatocellular carcinoma ; Liver ; Radiofrequency ablation ; Surgery ; Treatment outcome
Abstract
BACKGROUND & AIMS: The therapeutic outcomes of surgical resection (SR) or radiofrequency ablation (RFA) for perivascular hepatocellular carcinoma (HCC) have not been compared. The aim of this study was to compare SR with RFA as first-line treatment in patients with perivascular HCC and to evaluate the long-term outcomes of both therapies. METHODS: This retrospective study was approved by the institutional review board. The requirement for informed consent was waived. Between January 2006 and December 2010, a total of 283 consecutive patients with small perivascular HCCs (≤3 cm, Barcelona Clinic Liver Cancer stage 0 or A) underwent SR (n = 182) or RFA (n = 101) as a first-line treatment. The progression-free survival (PFS) and overall survival (OS) rates were compared by propensity score matching. Subgroup analysis of these outcomes was conducted according to the type of hepatic vessels. RESULTS: The median follow-up was 7.8 years. Matching yielded 62 pairs of patients. In the two matched groups, the PFS rates at 5 and 10 years were 58.0% and 17.8%, respectively, in the SR group, and 25.4% and 14.1%, respectively, in the RFA group (p <0.001). The corresponding OS rates at 5 and 10 years were 93.5% and 91.9% in the SR group and 82.3% and 74.1% in the RFA group, respectively (p <0.001). In contrast to those in patients with perivenous HCCs, subgroup analysis indicated that extrahepatic recurrence and OS were significantly different according to the treatment modality in patients with periportal HCCs (p = 0.004 and p <0.001, respectively). CONCLUSIONS: In patients with small perivascular HCCs, SR provided better long-term tumor control and OS than RFA, particularly for periportal tumors. LAY SUMMARY: Surgical resection and radiofrequency ablation are both treatment options for perivascular hepatocellular carcinoma. We compared outcomes in patients treated with either method. Surgical resection provided better long-term tumor control and overall survival than radiofrequency ablation for patients with a small perivascular hepatocellular carcinoma (≤3 cm) as a first-line treatment, particularly for periportal tumors. The location of the tumor and the type of peritumoral hepatic vessels need to be considered when choosing between surgical resection and radiofrequency ablation for small HCCs.
Full Text
https://www.sciencedirect.com/science/article/pii/S016882781830148X
DOI
10.1016/j.jhep.2018.02.026
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sunyoung(이선영) ORCID logo https://orcid.org/0000-0002-6893-3136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167183
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