Cited 16 times in
Treatment of Oligometastatic Hormone-Sensitive Prostate Cancer: A Comprehensive Review
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.date.accessioned | 2019-02-12T16:48:42Z | - |
dc.date.available | 2019-02-12T16:48:42Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167154 | - |
dc.description.abstract | With advancements in diagnostic techniques, including molecular and clinical imaging, that directly target cancer cells, oligometastatic prostate cancer (PCa) is being diagnosed in patients who were, in the past, considered to have localized disease. With accumulating evidence, there has been a paradigm shift in considering aggressive treatments targeted at both the primary tumor and metastatic lesions in an aim to avoid and delay the need for palliative treatments and, ultimately, to achieve survival benefits. However, many questions still remain unanswered regarding the understanding of oligometastatic PCa, from its definition to optimal treatment strategies for each individual. Limited retrospective studies have suggested that interventions, including local and/or metastasis-directed therapy using surgery and radiation therapy (RT), can improve survival outcomes with minimal risk of adverse effects. Such treatments have been shown to decrease the risks of subsequent palliative interventions and to delay the start of androgen-deprivation therapy. Nevertheless, available data are insufficient to draw a reliable conclusion regarding their effect on quality of life measures and overall survival. This comprehensive review overviews data from contemporary literature that have investigated treatments, including surgery and RT, for patients with oligometastatic PCa, namely pelvic lymph node positive disease and limited distant metastases, and summarizes ongoing trials that are evaluating the feasibility of aggressive multimodal treatments. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Node Excision/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Metastasis/therapy* | - |
dc.subject.MESH | Palliative Care | - |
dc.subject.MESH | Prostatectomy* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology | - |
dc.subject.MESH | Prostatic Neoplasms/radiotherapy* | - |
dc.subject.MESH | Prostatic Neoplasms/surgery* | - |
dc.subject.MESH | Quality of Life | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Treatment of Oligometastatic Hormone-Sensitive Prostate Cancer: A Comprehensive Review | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Prokar Dasgupta | - |
dc.identifier.doi | 10.3349/ymj.2018.59.5.567 | - |
dc.contributor.localId | A00188 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 29869454 | - |
dc.subject.keyword | Neoplasm metastasis | - |
dc.subject.keyword | hormones | - |
dc.subject.keyword | oligometastasis | - |
dc.subject.keyword | prostate cancer | - |
dc.subject.keyword | prostatectomy | - |
dc.subject.keyword | radiotherapy | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | 구교철 | - |
dc.citation.volume | 59 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 567 | - |
dc.citation.endPage | 579 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.59(5) : 567-579, 2018 | - |
dc.identifier.rimsid | 58133 | - |
dc.type.rims | ART | - |
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