Cited 5 times in
Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송정식 | - |
dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2019-02-12T16:48:00Z | - |
dc.date.available | 2019-02-12T16:48:00Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167148 | - |
dc.description.abstract | Background: To evaluate the therapeutic benefits of the treat-to-target (T2T) strategy for Asian patients with early rheumatoid arthritis (RA) in Korea. Methods: In a 1-year, multicenter, open-label strategy trial, 346 patients with early RA were recruited from 20 institutions across Korea and stratified into 2 groups, depending on whether they were recruited by rheumatologists who have adopted the T2T strategy (T2T group) or by rheumatologists who provided usual care (non-T2T group). Data regarding demographics, rheumatoid factor titer, anti-cyclic citrullinated peptide antibody titer, disease activity score of 28 joints (DAS28), and Korean Health Assessment Questionnaire (KHAQ) score were obtained at baseline and after 1 year of treatment. In the T2T group, the prescription for disease-modifying antirheumatic drugs was tailored to the predefined treatment target in each patient, namely remission (DAS28 < 2.6) or low disease activity (LDA) (2.6 ≤ DAS28 < 3.2). Results: Data were available for 163 T2T patients and 162 non-T2T patients. At the end of the study period, clinical outcomes were better in the T2T group than in the non-T2T group (LDA or remission, 59.5% vs. 35.8%; P < 0.001; remission, 43.6% vs. 19.8%; P < 0.001). Compared with non-T2T, T2T was also associated with higher rate of good European League Against Rheumatism response (63.0% vs. 39.8%; P < 0.001), improved KHAQ scores (-0.38 vs. -0.13; P = 0.008), and higher frequency of follow-up visits (5.0 vs. 2.0 visits/year; P < 0.001). Conclusion: In Asian patients with early RA, T2T improves disease activity and physical function. Setting a pre-defined treatment target in terms of DAS28 is recommended. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.contributor.googleauthor | Yeong Wook Song | - |
dc.contributor.googleauthor | Sang Cheol Bae | - |
dc.contributor.googleauthor | Hoon-Suk Cha | - |
dc.contributor.googleauthor | Jung-Yoon Choe | - |
dc.contributor.googleauthor | Sung Jae Choi | - |
dc.contributor.googleauthor | Hyun Ah Kim | - |
dc.contributor.googleauthor | Jinseok Kim | - |
dc.contributor.googleauthor | Sung-Soo Kim | - |
dc.contributor.googleauthor | Choong-Ki Lee | - |
dc.contributor.googleauthor | Jisoo Lee | - |
dc.contributor.googleauthor | Sang-Heon Lee | - |
dc.contributor.googleauthor | Shin-Seok Lee | - |
dc.contributor.googleauthor | Soo-Kon Lee | - |
dc.contributor.googleauthor | Sun Won Lee | - |
dc.contributor.googleauthor | Sung-Hwan Park | - |
dc.contributor.googleauthor | Won Park | - |
dc.contributor.googleauthor | Seung Cheol Shim | - |
dc.contributor.googleauthor | Chang-Hee Suh | - |
dc.contributor.googleauthor | Bin Yoo | - |
dc.contributor.googleauthor | Dae-Hyun Yoo | - |
dc.contributor.googleauthor | Wan-Hee Yoo | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e346 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02889 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 30584418 | - |
dc.subject.keyword | Rheumatoid Arthritis | - |
dc.subject.keyword | Treat-to-target | - |
dc.subject.keyword | Treatment Outcome | - |
dc.contributor.alternativeName | Song, Jung Sik | - |
dc.contributor.affiliatedAuthor | 송정식 | - |
dc.contributor.affiliatedAuthor | 이수곤 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 52 | - |
dc.citation.startPage | e346 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.33(52) : e346, 2018 | - |
dc.identifier.rimsid | 58128 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.