Cited 12 times in
Suppression of PROX1-mediated TERT expression in hepatitis B viral hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.contributor.author | 유정은 | - |
dc.contributor.author | Chong, Jae Uk | - |
dc.contributor.author | 최기홍 | - |
dc.date.accessioned | 2019-02-12T16:46:59Z | - |
dc.date.available | 2019-02-12T16:46:59Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167142 | - |
dc.description.abstract | Somatic mutations in the telomerase reverse transcriptase (TERT) promoter are related to telomerase activation and frequently occur at two hot spots located at -124 and -146 bp relative to the start codon in various cancers. Here, we investigated the occurrence and implications of genetic alterations in the TERT promoter in hepatitis B viral hepatocellular carcinoma (B viral HCC). TERT promoter mutations, especially -124C>T, clearly enhanced transcriptional activity in HCC cell lines. In contrast, TERT mRNA expression was lower in B viral HCC patients with TERT promoter mutations than in those without. We identified prospero homeobox protein 1 (PROX1) as a novel transcriptional activator of TERT; this protein was shown to have particularly strong binding affinity for the mutant TERT promoter. However, stable expression of the hepatitis B virus X (HBx) protein inhibited PROX1-mediated TERT expression in vitro. Our data suggest that TERT promoter mutations can enhance the promoter activity in HCC cell lines expressing PROX1 but are not the predominant mechanism of TERT upregulation in B viral HCC patients, based on the inhibition of PROX1-dependent transcriptional activation by HBx. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Suppression of PROX1-mediated TERT expression in hepatitis B viral hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Young‐Joo Kim | - |
dc.contributor.googleauthor | Jeong Eun Yoo | - |
dc.contributor.googleauthor | Youngsic Jeon | - |
dc.contributor.googleauthor | Jae Uk Chong | - |
dc.contributor.googleauthor | Gi Hong Choi | - |
dc.contributor.googleauthor | Dae‐Geun Song | - |
dc.contributor.googleauthor | Sang Hoon Jung | - |
dc.contributor.googleauthor | Bong‐Kyeong Oh | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.identifier.doi | 10.1002/ijc.31731 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A02504 | - |
dc.contributor.localId | 정재욱 | - |
dc.contributor.localId | A04046 | - |
dc.relation.journalcode | J01092 | - |
dc.identifier.eissn | 1097-0215 | - |
dc.identifier.pmid | 29987895 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.31731 | - |
dc.subject.keyword | B viral hepatocellular carcinoma | - |
dc.subject.keyword | HBx | - |
dc.subject.keyword | PROX1 | - |
dc.subject.keyword | TERT promoter mutation | - |
dc.subject.keyword | transcription factor | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.contributor.affiliatedAuthor | 유정은 | - |
dc.contributor.affiliatedAuthor | Chong, Jae Uk | - |
dc.contributor.affiliatedAuthor | 최기홍 | - |
dc.citation.volume | 143 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3155 | - |
dc.citation.endPage | 3168 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, Vol.143(12) : 3155-3168, 2018 | - |
dc.identifier.rimsid | 58122 | - |
dc.type.rims | ART | - |
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