Cited 15 times in
Hyponatremia Predicts New-Onset Cardiovascular Events in Peritoneal Dialysis Patients
DC Field | Value | Language |
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dc.contributor.author | 박철호 | - |
dc.contributor.author | 김형우 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 류근우 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 최규헌 | - |
dc.contributor.author | 한대석 | - |
dc.date.accessioned | 2019-01-18T16:40:08Z | - |
dc.date.available | 2019-01-18T16:40:08Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166902 | - |
dc.description.abstract | BACKGROUND AND AIM: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients on peritoneal dialysis (PD). Hyponatremia was recently shown to be a modifiable factor that is strongly associated with increased mortality in PD patients. However, the clinical impact of hyponatremia on CV outcomes in these patients is unclear. METHODS: To determine whether a low serum sodium level predicts the development of CV disease, we carried out a prospective observational study of 441 incident patients who started PD between January 2000 and December 2005. Time-averaged serum sodium (TA-Na) levels were determined to investigate the ability of hyponatremia to predict newly developed CV events in these patients. RESULTS: During a mean follow-up of 43.2 months, 106 (24.0%) patients developed new CV events. The cumulative incidence of new-onset CV events after the initiation of PD was significantly higher in patients with TA-Na levels ≤ 138 mEq/L than in those with a TA-Na > 138 mEq/L. After adjustment for multiple potentially confounding covariates, an increase in TA-Na level was found to be associated with a significantly lower risk of CV events (subdistribution hazard ratio per 1 mEq/L increase, 0.90; 95% confidence interval, 0.83-0.96; p = 0.003). Patients with a TA-Na ≤ 138 mEq/L had a 2.31-fold higher risk of suffering a CV event. CONCLUSIONS: These results provide evidence of a clear association between low serum sodium and new-onset CV events after dialysis initiation in PD patients. Whether the correction of hyponatremia for this indication provides additional protection for the development of CV disease in these patients remains to be addressed in interventional studies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cardiovascular Diseases/etiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyponatremia/complications* | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Peritoneal Dialysis* | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Hyponatremia Predicts New-Onset Cardiovascular Events in Peritoneal Dialysis Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Hyung Woo Kim | - |
dc.contributor.googleauthor | Geun Woo Ryu | - |
dc.contributor.googleauthor | Cheol Ho Park | - |
dc.contributor.googleauthor | Ea Wha Kang | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Sug Kyun Shin | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Dae Suk Han | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.identifier.doi | 10.1371/journal.pone.0129480 | - |
dc.contributor.localId | A01721 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 26053619 | - |
dc.contributor.alternativeName | Park, Cheol Ho | - |
dc.contributor.affiliatedAuthor | 박철호 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | e0129480 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.10(6) : e0129480, 2015 | - |
dc.identifier.rimsid | 64943 | - |
dc.type.rims | ART | - |
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