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Aminotransferase levels, body mass index, and the risk of diabetes: a prospective cohort study

DC FieldValueLanguage
dc.contributor.author김현창-
dc.contributor.author서일-
dc.contributor.author이주미-
dc.date.accessioned2019-01-15T17:10:44Z-
dc.date.available2019-01-15T17:10:44Z-
dc.date.issued2018-
dc.identifier.issn1047-2797-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166848-
dc.description.abstractPURPOSE: To investigate whether the relationship between body mass index (BMI) and incident diabetes is modified by different alanine or aspartate aminotransferases (ALT or AST) levels. METHODS: We carried out an analysis of 6484 participants aged 40 years or older using data from the Korean Genome Epidemiology Study. The serum aminotransferase levels were stratified into low and high groups according to the median values and classified into three groups: both low, either high, and both high. To assess the association between BMI and incident diabetes according to the serum aminotransferase levels, multiple logistic regression models were used. RESULTS: In participants with high levels of both ALT and AST, compared with the first BMI quartile, the adjusted odds ratios for incident diabetes of the second, third, and fourth BMI quartiles were 1.72 (95% confidence interval, 0.84-3.55), 2.19 (1.11-4.33), and 3.08 (1.60-5.90), respectively (P trend < .001). In participants with either high ALT or AST, the adjusted odds ratios were 3.58 (1.23-10.41), 2.65 (0.90-7.76), and 5.28 (1.86-15.02), respectively (P trend = .005). However, in participants with both low ALT and AST levels, high BMI was not independently associated with the risk of incident diabetes. CONCLUSIONS: There was a strong association between BMI and incident diabetes among individuals with high aminotransferase levels, whereas no association was observed among those with low aminotransferase levels.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfAnnals of Epidemiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAminotransferase levels, body mass index, and the risk of diabetes: a prospective cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine and Public Health (예방의학교실)-
dc.contributor.googleauthorBo Mi Song-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorDae Jung Kim-
dc.contributor.googleauthorSong Vogue Ahn-
dc.contributor.googleauthorKyoung Min Kim-
dc.contributor.googleauthorJu-Mi Lee-
dc.contributor.googleauthorSang-Baek Koh-
dc.contributor.googleauthorIl Suh-
dc.identifier.doi10.1016/j.annepidem.2018.07.009-
dc.contributor.localIdA01142-
dc.contributor.localIdA01899-
dc.contributor.localIdA01899-
dc.contributor.localIdA03157-
dc.contributor.localIdA03157-
dc.relation.journalcodeJ00159-
dc.identifier.eissn1873-2585-
dc.identifier.pmid30075987-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1047279717304933-
dc.subject.keywordALT-
dc.subject.keywordAST-
dc.subject.keywordDiabetes-
dc.subject.keywordKorean-
dc.subject.keywordObesity-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor서일-
dc.contributor.affiliatedAuthor서일-
dc.contributor.affiliatedAuthor이주미-
dc.contributor.affiliatedAuthor이주미-
dc.citation.volume28-
dc.citation.number10-
dc.citation.startPage675-
dc.citation.endPage680-
dc.identifier.bibliographicCitationAnnals of Epidemiology, Vol.28(10) : 675-680, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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