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Association Between Nonalcoholic Fatty Liver Disease and Intraocular Pressure in Korean Adults

 Kwon, Yu-Jin  ;  Kim, Ji-Hye  ;  Jung, Dong-Hyuk 
 Journal of Glaucoma, Vol.27(12) : 1099-1104, 2018 
Journal Title
 Journal of Glaucoma 
Issue Date
PURPOSE: Elevated intraocular pressure (IOP) is an important modifiable risk factor predicting glaucoma progression. Recent studies have demonstrated that metabolic risk factors influence IOP. Nonalcoholic fatty liver (NAFLD) is an emerging chronic liver disease that is closely associated with metabolic syndrome, obesity, and type 2 diabetes. Therefore, we investigated the relationship between NAFLD and intraocular pressure in Korean adults. PATIENTS AND METHODS: This retrospective cross-sectional study analyzed a total of 7681 participants who visited a local health promotion center. NAFLD was defined via ultrasonography and patients were classified into 3 groups based on severity: normal, mild, and moderate to severe. We conducted multiple logistic regression analysis to examine the relationship between NAFLD and high IOP. We additionally performed multiple linear regression analysis to investigate the independent association between NAFLD and mean IOP. RESULTS: Mean IOP levels significantly and linearly increased with increasing NAFLD grades. Compared with normal, the odds ratio and 95% confidence intervals for high IOP were 1.09 (0.96-1.24) for mild NAFLD and 1.28 (1.12-1.48) for moderate to severe NAFLD after adjusting for confounding factors. NAFLD severity was noticed as an independent factor associated with mean IOP levels using stepwise and enter methods for multiple linear regression analyses. CONCLUSIONS: NAFLD severity was associated with high IOP (>15 mm Hg) in Korean adults in a dose-dependent manner.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
권유진(Kwon, Yu-Jin) ORCID logo https://orcid.org/0000-0002-9021-3856
김지혜(Kim, Ji-Hye) ORCID logo https://orcid.org/0000-0002-5719-8180
정동혁(Jung, Dong Hyuk) ORCID logo https://orcid.org/0000-0002-3411-0676
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