23 23

Cited 0 times in

Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity

Authors
 A Reum Kim  ;  Junsik Park  ;  Jong Hoon Kim  ;  Jeong-Eun Kwak  ;  Youngran Cho  ;  Hyojin Lee  ;  Moonsup Jeong  ;  Su-Hyung Park  ;  Eui-Cheol Shin 
Citation
 Immune Network, Vol.18(5) : e38, 2018 
Journal Title
 Immune Network 
ISSN
 1598-2629 
Issue Date
2018
Keywords
DNA vaccines ; Herpes zoster ; IL-33 ; IL-7 ; T-cells
Abstract
Herpes zoster (HZ), or shingles, is caused by the reactivation of latent varicella-zoster virus (VZV) from the sensory ganglia when VZV-specific T-cell immunity is decreased because of aging or immunosuppression. In the present study, we developed HZ DNA vaccine candidates encoding VZV proteins and cytokine adjuvants, such as IL-7 and IL-33. We immunized C57BL/6 mice with DNA plasmids encoding VZV glycoprotein E (gE), immediate early (IE) 63, or IE62 proteins and found that robust VZV protein-specific T-cell responses were elicited by HZ DNA vaccination. Co-administration of DNA plasmids encoding IL-7 or IL-33 in HZ DNA vaccination significantly enhanced the magnitude of VZV protein-specific T-cell responses. Protective immunity elicited by HZ DNA vaccination was proven by challenge experiments with a surrogate virus, vaccinia virus expressing gE (VV-gE). A single dose of HZ DNA vaccine strongly boosted gE-specific T-cell responses in mice with a history of previous infection by VV-gE. Thus, HZ DNA vaccines with IL-7 and IL-33 adjuvants strongly elicit protective immunity.
Files in This Item:
T201804756.pdf.pdf Download
DOI
10.4110/in.2018.18.e38
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
김종훈(Kim, Jong Hoon) ORCID logo https://orcid.org/0000-0002-3385-8180
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166816
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse