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The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Head and Neck Cancer Patients Treated with Radiotherapy

DC FieldValueLanguage
dc.contributor.author금기창-
dc.contributor.author김준원-
dc.contributor.author윤홍인-
dc.contributor.author이익재-
dc.contributor.author이창걸-
dc.contributor.author조연아-
dc.date.accessioned2019-01-15T17:05:19Z-
dc.date.available2019-01-15T17:05:19Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166797-
dc.description.abstractBACKGROUND: To investigate the prognostic value of pre-treatment neutrophil/lymphocyte ratio (NLR) in patients treated with definitive radiotherapy (RT) for head and neck cancer. METHODS: We retrospectively analyzed 621 patients who received definitive RT for nasopharyngeal, oropharyngeal, hypopharyngeal, and laryngeal cancer. An NLR cut-off value of 2.7 was identified using a receiver operating characteristic curve analysis, with overall survival (OS) as an endpoint. RESULTS: The 5-year progression-free survival (PFS) and OS for all patients were 62.3% and 72.1%, respectively. The patients with a high NLR (68%) had a significantly lower 5-year PFS and OS than their counterparts with a low NLR (32%) (PFS: 39.2% vs. 75.8%, p < 0.001; OS: 50.9% vs. 83.8%, p < 0.001). In a subgroup analysis according to primary site, a high NLR also correlated with a lower PFS and OS, except in oropharyngeal cancer, where a high NLR only exhibited a trend towards lower survival. In a multivariate analysis, a high NLR remained an independent prognostic factor for PFS and OS. CONCLUSION: Head and neck cancer tends to be more aggressive in patients with a high NLR, leading to a poorer outcome after RT. The optimal therapeutic approaches for these patients should be reevaluated, given the unfavorable prognosis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Head and Neck Cancer Patients Treated with Radiotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorYeona Cho-
dc.contributor.googleauthorJun Won Kim-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorChang Geol Lee-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorIk Jae Lee-
dc.identifier.doi10.3390/jcm7120512-
dc.contributor.localIdA00272-
dc.contributor.localIdA00958-
dc.contributor.localIdA00958-
dc.contributor.localIdA04777-
dc.contributor.localIdA04777-
dc.contributor.localIdA03055-
dc.contributor.localIdA03055-
dc.contributor.localIdA03240-
dc.contributor.localIdA03240-
dc.contributor.localIdA04680-
dc.contributor.localIdA04680-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid30513928-
dc.subject.keywordhead and neck cancer-
dc.subject.keywordneutrophil/lymphocyte ratio-
dc.subject.keywordradiotherapy-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.affiliatedAuthor금기창-
dc.contributor.affiliatedAuthor김준원-
dc.contributor.affiliatedAuthor김준원-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor이익재-
dc.contributor.affiliatedAuthor이익재-
dc.contributor.affiliatedAuthor이창걸-
dc.contributor.affiliatedAuthor이창걸-
dc.contributor.affiliatedAuthor조연아-
dc.contributor.affiliatedAuthor조연아-
dc.citation.volume7-
dc.citation.number12-
dc.citation.startPageE512-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.7(12) : E512, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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