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Predictive value of preoperative monocyte-lymphocyte ratio among patients with localized clear renal cell carcinoma of ≤7 cm on preoperative imaging

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dc.contributor.author김종찬-
dc.contributor.author나군호-
dc.contributor.author박지수-
dc.contributor.author장원식-
dc.contributor.author최영득-
dc.contributor.author함원식-
dc.contributor.author허지은-
dc.date.accessioned2019-01-15T17:04:58Z-
dc.date.available2019-01-15T17:04:58Z-
dc.date.issued2018-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166795-
dc.description.abstractWe investigated the prognostic ability of preoperative monocyte-lymphocyte ratio for oncologic outcomes in non-metastatic clear cell renal cell carcinoma of ≤7 cm on preoperative computed tomography (CT).We retrospectively reviewed 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤7 cm (2005-2014). We included 1137 patients after exclusion of benign pathology, non-clear cell, morbidity affecting inflammatory markers, metastasis, regional lymphadenopathy, positive margin, and follow up <12 months. According to cutoff values of 0.21, we had high ≥0.21 and low <0.21 preoperative monocyte-lymphocyte ratio groups. Mann-Whitney U and chi-squared tests were used for continuous and Dichotomous variables. Univariate and multivariate Cox regression analysis were used to predict factors affecting recurrence and survival. Kaplan-Meier curve was used for survival analysis.At a median age of 56 years with a median follow up of 65 months, 51 patients had a recurrence (4.5%). There were no statistical differences between the high and low monocyte-lymphocyte ratio groups as regard the pathological characters (P > .005). Monocyte-lymphocyte ratio was a predictor for recurrence-free and cancer-specific survivals (hazard risk [HR] 2.17, P = .012 and HR 4.06, P = .004, respectively). A higher monocyte-lymphocyte ratio was significantly associated with worse, both 10-year recurrence-free (90.2% vs 94.9%) and cancer-specific survival (89.5% vs 98.8%) (Log-rank, P = .002 and P < .001, respectively).The preoperative monocyte-lymphocyte ratio is an independent prognostic marker for recurrence-free and cancer-specific survivals after curative surgery for non-metastatic clear cell renal cell carcinoma of ≤7 cm on preoperative CT.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/blood-
dc.subject.MESHCarcinoma, Renal Cell/blood*-
dc.subject.MESHCarcinoma, Renal Cell/immunology-
dc.subject.MESHCarcinoma, Renal Cell/mortality-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHKidney Neoplasms/blood*-
dc.subject.MESHKidney Neoplasms/immunology-
dc.subject.MESHKidney Neoplasms/mortality-
dc.subject.MESHLymphocyte Count-
dc.subject.MESHLymphocytes*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMonocytes*-
dc.subject.MESHNeoplasm Recurrence, Local/blood-
dc.subject.MESHNeoplasm Recurrence, Local/immunology-
dc.subject.MESHNeoplasm Recurrence, Local/mortality-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPreoperative Period-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.titlePredictive value of preoperative monocyte-lymphocyte ratio among patients with localized clear renal cell carcinoma of ≤7 cm on preoperative imaging-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.googleauthorAhmed Elghiaty-
dc.contributor.googleauthorJongchan Kim-
dc.contributor.googleauthorWon Sik Jang-
dc.contributor.googleauthorJee Soo Park-
dc.contributor.googleauthorJi Eun Heo-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorWon Sik Ham-
dc.identifier.doi10.1097/MD.0000000000013433-
dc.contributor.localIdA04541-
dc.contributor.localIdA01227-
dc.contributor.localIdA05336-
dc.contributor.localIdA05268-
dc.contributor.localIdA04111-
dc.contributor.localIdA04337-
dc.contributor.localIdA05531-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid30508956-
dc.contributor.alternativeNameKim, Jong Chan-
dc.contributor.affiliatedAuthor김종찬-
dc.contributor.affiliatedAuthor나군호-
dc.contributor.affiliatedAuthor박지수-
dc.contributor.affiliatedAuthor장원식-
dc.contributor.affiliatedAuthor최영득-
dc.contributor.affiliatedAuthor함원식-
dc.contributor.affiliatedAuthor허지은-
dc.citation.volume97-
dc.citation.number48-
dc.citation.startPagee13433-
dc.identifier.bibliographicCitationMEDICINE, Vol.97(48) : e13433, 2018-
dc.identifier.rimsid58061-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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