Cited 3 times in
Predictive value of preoperative monocyte-lymphocyte ratio among patients with localized clear renal cell carcinoma of ≤7 cm on preoperative imaging
DC Field | Value | Language |
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dc.contributor.author | 김종찬 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 박지수 | - |
dc.contributor.author | 장원식 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 함원식 | - |
dc.contributor.author | 허지은 | - |
dc.date.accessioned | 2019-01-15T17:04:58Z | - |
dc.date.available | 2019-01-15T17:04:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166795 | - |
dc.description.abstract | We investigated the prognostic ability of preoperative monocyte-lymphocyte ratio for oncologic outcomes in non-metastatic clear cell renal cell carcinoma of ≤7 cm on preoperative computed tomography (CT).We retrospectively reviewed 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤7 cm (2005-2014). We included 1137 patients after exclusion of benign pathology, non-clear cell, morbidity affecting inflammatory markers, metastasis, regional lymphadenopathy, positive margin, and follow up <12 months. According to cutoff values of 0.21, we had high ≥0.21 and low <0.21 preoperative monocyte-lymphocyte ratio groups. Mann-Whitney U and chi-squared tests were used for continuous and Dichotomous variables. Univariate and multivariate Cox regression analysis were used to predict factors affecting recurrence and survival. Kaplan-Meier curve was used for survival analysis.At a median age of 56 years with a median follow up of 65 months, 51 patients had a recurrence (4.5%). There were no statistical differences between the high and low monocyte-lymphocyte ratio groups as regard the pathological characters (P > .005). Monocyte-lymphocyte ratio was a predictor for recurrence-free and cancer-specific survivals (hazard risk [HR] 2.17, P = .012 and HR 4.06, P = .004, respectively). A higher monocyte-lymphocyte ratio was significantly associated with worse, both 10-year recurrence-free (90.2% vs 94.9%) and cancer-specific survival (89.5% vs 98.8%) (Log-rank, P = .002 and P < .001, respectively).The preoperative monocyte-lymphocyte ratio is an independent prognostic marker for recurrence-free and cancer-specific survivals after curative surgery for non-metastatic clear cell renal cell carcinoma of ≤7 cm on preoperative CT. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/blood | - |
dc.subject.MESH | Carcinoma, Renal Cell/blood* | - |
dc.subject.MESH | Carcinoma, Renal Cell/immunology | - |
dc.subject.MESH | Carcinoma, Renal Cell/mortality | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Kidney Neoplasms/blood* | - |
dc.subject.MESH | Kidney Neoplasms/immunology | - |
dc.subject.MESH | Kidney Neoplasms/mortality | - |
dc.subject.MESH | Lymphocyte Count | - |
dc.subject.MESH | Lymphocytes* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monocytes* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/blood | - |
dc.subject.MESH | Neoplasm Recurrence, Local/immunology | - |
dc.subject.MESH | Neoplasm Recurrence, Local/mortality | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Preoperative Period | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Predictive value of preoperative monocyte-lymphocyte ratio among patients with localized clear renal cell carcinoma of ≤7 cm on preoperative imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Ahmed Elghiaty | - |
dc.contributor.googleauthor | Jongchan Kim | - |
dc.contributor.googleauthor | Won Sik Jang | - |
dc.contributor.googleauthor | Jee Soo Park | - |
dc.contributor.googleauthor | Ji Eun Heo | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Won Sik Ham | - |
dc.identifier.doi | 10.1097/MD.0000000000013433 | - |
dc.contributor.localId | A04541 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A05336 | - |
dc.contributor.localId | A05268 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04337 | - |
dc.contributor.localId | A05531 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 30508956 | - |
dc.contributor.alternativeName | Kim, Jong Chan | - |
dc.contributor.affiliatedAuthor | 김종찬 | - |
dc.contributor.affiliatedAuthor | 나군호 | - |
dc.contributor.affiliatedAuthor | 박지수 | - |
dc.contributor.affiliatedAuthor | 장원식 | - |
dc.contributor.affiliatedAuthor | 최영득 | - |
dc.contributor.affiliatedAuthor | 함원식 | - |
dc.contributor.affiliatedAuthor | 허지은 | - |
dc.citation.volume | 97 | - |
dc.citation.number | 48 | - |
dc.citation.startPage | e13433 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.97(48) : e13433, 2018 | - |
dc.identifier.rimsid | 58061 | - |
dc.type.rims | ART | - |
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