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Prognostic value of age adjusted segment involvement score as measured by coronary computed tomography: a potential marker of vascular age
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2019-01-15T17:03:21Z | - |
dc.date.available | 2019-01-15T17:03:21Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0910-8327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166777 | - |
dc.description.abstract | Extent of coronary atherosclerotic disease (CAD) burden on coronary computed tomography angiography (CCTA) as measured by segment involvement score (SIS) has a prognostic value. We sought to investigate the incremental prognostic value of 'age adjusted SIS' (aSIS), which may be a marker of premature atherosclerosis and vascular age. Consecutive patients were prospectively enrolled into the CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicentre) multinational observational study. Patients were followed for the outcome of all-cause death. aSIS was calculated on CCTA for each patient, and its incremental prognostic value was evaluated. A total of 22,211 patients [mean age 58.5 ± 12.7 years, 55.8% male) with a median follow-up of 27.3 months (IQR 17.8, 35.4)] were identified. After adjustment for clinical factors and presence of obstructive CAD, higher aSIS was associated with increased death on multivariable analysis, with hazard ratio (HR) 2.40 (1.83-3.16, p < 0.001), C-statistic 0.723 (0.700-0.756), net reclassification improvement (NRI) 0.36 (0.26-0.47, p < 0.001), and relative integrated discrimination improvement (IDI) 0.33 (p = 0.009). aSIS had HR 3.48 (2.33-5.18, p < 0.001) for mortality in those without obstructive CAD, compared to HR 1.79 (1.25-2.58, p = 0.02) in those with obstructive CAD. In conclusion, aSIS has an incremental prognostic value to traditional risk factors and obstructive CAD, and may enhance CCTA risk stratification. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | HEART AND VESSELS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Prognostic value of age adjusted segment involvement score as measured by coronary computed tomography: a potential marker of vascular age | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Chadi Ayoub | - |
dc.contributor.googleauthor | Leonard Kritharides | - |
dc.contributor.googleauthor | Yeung Yam | - |
dc.contributor.googleauthor | Li Chen | - |
dc.contributor.googleauthor | Alomgir Hossain | - |
dc.contributor.googleauthor | Stephan Achenbach | - |
dc.contributor.googleauthor | Mouaz H. Al-Mallah | - |
dc.contributor.googleauthor | Daniele Andreini | - |
dc.contributor.googleauthor | Daniel S. Berman | - |
dc.contributor.googleauthor | Matthew J. Budoff | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Tracy Q. Callister | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Ricardo C. Cury | - |
dc.contributor.googleauthor | Augustin Delago | - |
dc.contributor.googleauthor | Allison Dunning | - |
dc.contributor.googleauthor | Gudrun Feuchtner | - |
dc.contributor.googleauthor | Millie Gomez | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Joerg Hausleiter | - |
dc.contributor.googleauthor | Niree Hindoyan | - |
dc.contributor.googleauthor | Philipp A. Kaufmann | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Jonathon Leipsic | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Hugo Marques | - |
dc.contributor.googleauthor | Gianluca Pontone | - |
dc.contributor.googleauthor | Gilbert Raff | - |
dc.contributor.googleauthor | Ronen Rubinshtein | - |
dc.contributor.googleauthor | Leslee J. Shaw | - |
dc.contributor.googleauthor | Todd C. Villines | - |
dc.contributor.googleauthor | James K. Min | - |
dc.contributor.googleauthor | Benjamin J. W. Chow | - |
dc.identifier.doi | 10.1007/s00380-018-1188-3 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00978 | - |
dc.identifier.eissn | 1615-2573 | - |
dc.identifier.pmid | 29797058 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00380-018-1188-3 | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Computed tomography | - |
dc.subject.keyword | Coronary | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1288 | - |
dc.citation.endPage | 1300 | - |
dc.identifier.bibliographicCitation | HEART AND VESSELS, Vol.33(11) : 1288-1300, 2018 | - |
dc.identifier.rimsid | 58045 | - |
dc.type.rims | ART | - |
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