555 553

Cited 19 times in

Serotonin signals through a gut-liver axis to regulate hepatic steatosis

DC Field Value Language
dc.contributor.author박준용-
dc.contributor.author이혜원-
dc.contributor.author한광협-
dc.date.accessioned2019-01-15T16:53:59Z-
dc.date.available2019-01-15T16:53:59Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166706-
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking. Defining the key molecular pathways underlying the pathogenesis of NAFLD is essential for developing new drugs. Here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A (HTR2A) signaling. Local serotonin concentrations in the portal blood, which can directly travel to and affect the liver, are selectively increased by high-fat diet (HFD) feeding in mice. Both gut-specific Tph1 knockout mice and liver-specific Htr2a knockout mice are resistant to HFD-induced hepatic steatosis, without affecting systemic energy homeostasis. Moreover, selective HTR2A antagonist treatment prevents HFD-induced hepatic steatosis. Thus, the gut TPH1-liver HTR2A axis shows promise as a drug target to ameliorate NAFLD with minimal systemic metabolic effects.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHDiet, High-Fat/adverse effects-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHHumans-
dc.subject.MESHHypolipidemic Agents/pharmacology-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHIntestinal Mucosa/metabolism*-
dc.subject.MESHIntestinal Mucosa/pathology-
dc.subject.MESHLipid Metabolism-
dc.subject.MESHLiver/metabolism*-
dc.subject.MESHLiver/pathology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Knockout-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/etiology-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/genetics*-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/pathology-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/prevention & control-
dc.subject.MESHReceptor, Serotonin, 5-HT2A/deficiency-
dc.subject.MESHReceptor, Serotonin, 5-HT2A/genetics*-
dc.subject.MESHSerotonin/metabolism*-
dc.subject.MESHSerotonin Antagonists/pharmacology-
dc.subject.MESHSignal Transduction-
dc.subject.MESHSuccinates/pharmacology-
dc.subject.MESHTryptophan Hydroxylase/deficiency-
dc.subject.MESHTryptophan Hydroxylase/genetics*-
dc.titleSerotonin signals through a gut-liver axis to regulate hepatic steatosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorWonsuk Choi-
dc.contributor.googleauthorJun Namkung-
dc.contributor.googleauthorInseon Hwang-
dc.contributor.googleauthorHyeongseok Kim-
dc.contributor.googleauthorAjin Lim-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorSeongyeol Park-
dc.contributor.googleauthorJi-Seon Jeong-
dc.contributor.googleauthorGeul Bang-
dc.contributor.googleauthorYoung Hwan Kim-
dc.contributor.googleauthorVijay K. Yadav-
dc.contributor.googleauthorGerard Karsenty-
dc.contributor.googleauthorYoung Seok Ju-
dc.contributor.googleauthorChan Choi-
dc.contributor.googleauthorJae Myoung Suh-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSangkyu Park-
dc.contributor.googleauthorHail Kim-
dc.identifier.doi10.1038/s41467-018-07287-7-
dc.contributor.localIdA01675-
dc.contributor.localIdA03318-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid30446669-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor이혜원-
dc.contributor.affiliatedAuthor한광협-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage4824-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.9(1) : 4824, 2018-
dc.identifier.rimsid57975-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.