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Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population

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dc.contributor.author강석구-
dc.contributor.author김세훈-
dc.contributor.author장종희-
dc.date.accessioned2019-01-15T16:53:05Z-
dc.date.available2019-01-15T16:53:05Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166702-
dc.description.abstractPrevious studies have identified multiple loci for inherited susceptibility to glioma development, including the regulator of telomere elongation helicase 1 (RTEL1). However, the association between RTEL1 variants and risk of glioma has not been well understood. Therefore, we sought to comprehensively examine the genetic interaction between RTEL1 variants and risk of glioma with respect to defined histological and molecular subtypes. We employed a case-control study involving 250 adult glioma patients with previous molecular alterations and 375 population-based controls within Korean populations. Statistical analyses on the association between RTEL1 single nucleotide polymorphisms (SNPs) and glioma risk were conducted using unconditional logistic regression. Additional conditional and stepwise analyses were performed on significant RTEL1 SNPs. We detected significant associations (Bonferroni P < .05) between six SNPs (rs6089953, rs3848669, rs6010620, rs3787089, rs6062302, and rs115303435) and risk of glioma in the Korean subjects. The two coding variants, rs6062302 (D664D) and rs115303435 (A1059T), were plausibly causal variants and were independent among the significantly associated RTEL1 variants. The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma regardless of histological grades and molecular alterations. This study provides a deeper understanding of relationships between RTEL1 variants and risk of glioma. Further studies are required to ascertain the impact of those variants on glioma susceptibility.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAssociation analysis of RTEL1 variants with risk of adult gliomas in a Korean population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorSuhg Namgoong1, Hyun Sub Cheong2, Jeong-Hyun Kim3, Lyoung Hyo Kim2, Jung Yeon Seo-
dc.contributor.googleauthorSeok-Gu Kang-
dc.contributor.googleauthorSeon-Jin Yoon-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorHyoung Doo Shin-
dc.identifier.doi10.1371/journal.pone.0207660-
dc.contributor.localIdA00036-
dc.contributor.localIdA00610-
dc.contributor.localIdA03470-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid30462709-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.affiliatedAuthor강석구-
dc.contributor.affiliatedAuthor김세훈-
dc.contributor.affiliatedAuthor장종희-
dc.citation.volume13-
dc.citation.number11-
dc.citation.startPagee207660-
dc.identifier.bibliographicCitationPLOS ONE, Vol.13(11) : e207660, 2018-
dc.identifier.rimsid57971-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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