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Regulation of proliferation and invasion by the IGF signalling pathway in Epstein-Barr virus-positive gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 라선영 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 권우선 | - |
dc.date.accessioned | 2019-01-15T16:52:38Z | - |
dc.date.available | 2019-01-15T16:52:38Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1582-1838 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166695 | - |
dc.description.abstract | Several carcinomas including gastric cancer have been reported to contain Epstein-Barr virus (EBV) infection. EBV-associated gastric cancer (EBVaGC) is classified as one of four molecular subtypes of gastric cancer by The Cancer Genome Atlas (TCGA) group with increased immune-related signatures. Identification of EBV-dependent pathways with significant biological roles is needed for EBVaGC. To compare the biological changes between AGS gastric epithelial cells and EBV-infected AGS (AGS-EBV) cells, proliferation assay, CCK-8 assay, invasion assay, cell cycle analysis, RT-PCR, Western blot and ELISA were performed. BI836845, a humanized insulin-like growth factor (IGF) ligand-neutralizing antibody, was used for IGF-related signalling pathway inhibition. AGS-EBV cells showed slower proliferating rate and higher sensitivity to BI836845 compared to AGS cells. Moreover, invasiveness of AGS-EBV was increased than that of AGS, and BI836845 treatment significantly decreased the invasiveness of AGS-EBV. Although no apoptosis was detected, entry into the S phase of the cell cycle was delayed in BI836845-treated AGS-EBV cells. In conclusion, AGS-EBV cells seem to modulate their proliferation and invasion through the IGF signalling pathway. Inhibition of the IGF signalling pathway therefore could be a potential therapeutic strategy for EBVaGC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Regulation of proliferation and invasion by the IGF signalling pathway in Epstein-Barr virus-positive gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Inhye Jeong | - |
dc.contributor.googleauthor | Sun Kyoung Kang | - |
dc.contributor.googleauthor | Woo Sun Kwon | - |
dc.contributor.googleauthor | Hyun Jeong Kim | - |
dc.contributor.googleauthor | Kyoo Hyun Kim | - |
dc.contributor.googleauthor | Hyun Myong Kim | - |
dc.contributor.googleauthor | Andre Lee | - |
dc.contributor.googleauthor | Suk Kyeong Lee | - |
dc.contributor.googleauthor | Thomas Bogenrieder | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.identifier.doi | 10.1111/jcmm.13859 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J01302 | - |
dc.identifier.eissn | 1582-4934 | - |
dc.identifier.pmid | 30247804 | - |
dc.subject.keyword | BI836845 | - |
dc.subject.keyword | IGF signalling pathway | - |
dc.subject.keyword | epstein-barr virus | - |
dc.subject.keyword | gastric cancer | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 5899 | - |
dc.citation.endPage | 5908 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Vol.22(12) : 5899-5908, 2018 | - |
dc.identifier.rimsid | 57964 | - |
dc.type.rims | ART | - |
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