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Casein Kinase 2 Inhibitor, CX-4945, as a Potential Targeted Anticancer Agent in Gastric Cancer

DC Field Value Language
dc.contributor.author김태수-
dc.contributor.author라선영-
dc.contributor.author박규현-
dc.contributor.author정민규-
dc.contributor.author정현철-
dc.contributor.author권우선-
dc.date.accessioned2019-01-15T16:52:27Z-
dc.date.available2019-01-15T16:52:27Z-
dc.date.issued2018-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166694-
dc.description.abstractBACKGROUND/AIM: Casein kinase 2 (CK2) is involved in multiple cellular processes. Furthermore, its overexpression in several human cancers has been associated with tumor progression. In this study, we evaluated the efficacy of the CK2 inhibitor, CX-4945, in gastric cancer cell lines and explored the potential predictive biomarkers for CX-4945 sensitivity. MATERIALS AND METHODS: The sensitivity to CX-4945 was screened in 49 gastric cancer cell lines by the MTT assay. The mRNA and protein expression of CK2 subunits (α and α') were determined using qRT-PCR and western blot. Furthermore, the activity of CK2α was measured by ELISA. Gene expression and mutations were analyzed via whole-exome and RNA sequencing. RESULTS: The sensitivity to CX-4945 was determined by the inhibition rate (%) at the effective dose (10 μM) which ranged from -1% to 89% in 49 gastric cancer cell lines. CK2α', but not CK2α, mRNA expression was correlated with CX-4945 sensitivity. CONCLUSION: In this study, CX-4945 showed modest antitumor efficacy in gastric cancer cell lines. CK2 might represent a potential therapeutic target for gastric cancer.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.isPartOfANTICANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCasein Kinase II/antagonists & inhibitors-
dc.subject.MESHCasein Kinase II/biosynthesis-
dc.subject.MESHCasein Kinase II/genetics-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHHumans-
dc.subject.MESHMolecular Targeted Therapy-
dc.subject.MESHMutation-
dc.subject.MESHNaphthyridines/pharmacology*-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHStomach Neoplasms/drug therapy*-
dc.subject.MESHStomach Neoplasms/enzymology*-
dc.subject.MESHStomach Neoplasms/genetics-
dc.titleCasein Kinase 2 Inhibitor, CX-4945, as a Potential Targeted Anticancer Agent in Gastric Cancer-
dc.typeArticle-
dc.contributor.collegeOthers-
dc.contributor.departmentSeverance Hospital (세브란스병원)-
dc.contributor.googleauthorHYUN MYONG KIM-
dc.contributor.googleauthorINHYE JEONG-
dc.contributor.googleauthorHYUN JEONG KIM-
dc.contributor.googleauthorSUN KYOUNG KANG-
dc.contributor.googleauthorWOO SUN KWON-
dc.contributor.googleauthorTAE SOO KIM-
dc.contributor.googleauthorKYU HYUN PARK-
dc.contributor.googleauthorMINKYU JUNG-
dc.contributor.googleauthorJOHN SOONG-
dc.contributor.googleauthorSHU-CHUAN LIN-
dc.contributor.googleauthorHYUN CHEOL CHUNG-
dc.contributor.googleauthorSUN YOUNG RHA-
dc.identifier.doi10.21873/anticanres.12970-
dc.contributor.localIdA04549-
dc.contributor.localIdA01316-
dc.contributor.localIdA04566-
dc.contributor.localIdA03606-
dc.contributor.localIdA03773-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid30396934-
dc.identifier.urlhttp://ar.iiarjournals.org/content/38/11/6171.long-
dc.contributor.alternativeNameKim, Tae Soo-
dc.contributor.affiliatedAuthor김태수-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor박규현-
dc.contributor.affiliatedAuthor정민규-
dc.contributor.affiliatedAuthor정현철-
dc.citation.volume38-
dc.citation.number11-
dc.citation.startPage6171-
dc.citation.endPage6180-
dc.identifier.bibliographicCitationANTICANCER RESEARCH, Vol.38(11) : 6171-6180, 2018-
dc.identifier.rimsid57963-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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