Cited 15 times in
Casein Kinase 2 Inhibitor, CX-4945, as a Potential Targeted Anticancer Agent in Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | 김태수 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 박규현 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 권우선 | - |
dc.date.accessioned | 2019-01-15T16:52:27Z | - |
dc.date.available | 2019-01-15T16:52:27Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166694 | - |
dc.description.abstract | BACKGROUND/AIM: Casein kinase 2 (CK2) is involved in multiple cellular processes. Furthermore, its overexpression in several human cancers has been associated with tumor progression. In this study, we evaluated the efficacy of the CK2 inhibitor, CX-4945, in gastric cancer cell lines and explored the potential predictive biomarkers for CX-4945 sensitivity. MATERIALS AND METHODS: The sensitivity to CX-4945 was screened in 49 gastric cancer cell lines by the MTT assay. The mRNA and protein expression of CK2 subunits (α and α') were determined using qRT-PCR and western blot. Furthermore, the activity of CK2α was measured by ELISA. Gene expression and mutations were analyzed via whole-exome and RNA sequencing. RESULTS: The sensitivity to CX-4945 was determined by the inhibition rate (%) at the effective dose (10 μM) which ranged from -1% to 89% in 49 gastric cancer cell lines. CK2α', but not CK2α, mRNA expression was correlated with CX-4945 sensitivity. CONCLUSION: In this study, CX-4945 showed modest antitumor efficacy in gastric cancer cell lines. CK2 might represent a potential therapeutic target for gastric cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Casein Kinase II/antagonists & inhibitors | - |
dc.subject.MESH | Casein Kinase II/biosynthesis | - |
dc.subject.MESH | Casein Kinase II/genetics | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Molecular Targeted Therapy | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Naphthyridines/pharmacology* | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Stomach Neoplasms/drug therapy* | - |
dc.subject.MESH | Stomach Neoplasms/enzymology* | - |
dc.subject.MESH | Stomach Neoplasms/genetics | - |
dc.title | Casein Kinase 2 Inhibitor, CX-4945, as a Potential Targeted Anticancer Agent in Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.college | Others | - |
dc.contributor.department | Severance Hospital (세브란스병원) | - |
dc.contributor.googleauthor | HYUN MYONG KIM | - |
dc.contributor.googleauthor | INHYE JEONG | - |
dc.contributor.googleauthor | HYUN JEONG KIM | - |
dc.contributor.googleauthor | SUN KYOUNG KANG | - |
dc.contributor.googleauthor | WOO SUN KWON | - |
dc.contributor.googleauthor | TAE SOO KIM | - |
dc.contributor.googleauthor | KYU HYUN PARK | - |
dc.contributor.googleauthor | MINKYU JUNG | - |
dc.contributor.googleauthor | JOHN SOONG | - |
dc.contributor.googleauthor | SHU-CHUAN LIN | - |
dc.contributor.googleauthor | HYUN CHEOL CHUNG | - |
dc.contributor.googleauthor | SUN YOUNG RHA | - |
dc.identifier.doi | 10.21873/anticanres.12970 | - |
dc.contributor.localId | A04549 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A04566 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 30396934 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/38/11/6171.long | - |
dc.contributor.alternativeName | Kim, Tae Soo | - |
dc.contributor.affiliatedAuthor | 김태수 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 박규현 | - |
dc.contributor.affiliatedAuthor | 정민규 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6171 | - |
dc.citation.endPage | 6180 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.38(11) : 6171-6180, 2018 | - |
dc.identifier.rimsid | 57963 | - |
dc.type.rims | ART | - |
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