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A nomogram for predicting survival of patients with locally advanced pancreatic cancer treated with chemoradiotherapy

DC FieldValueLanguage
dc.contributor.author박승우-
dc.contributor.author성진실-
dc.contributor.author최서희-
dc.date.accessioned2019-01-15T16:52:11Z-
dc.date.available2019-01-15T16:52:11Z-
dc.date.issued2018-
dc.identifier.issn0167-8140-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166691-
dc.description.abstractBACKGROUND: We developed a nomogram for predicting survival of patients with locally advanced pancreatic cancer (LAPC) after concurrent chemoradiotherapy (CRT) using 18F-flurodeoxyglucose-positron emission tomography (FDG-PET) parameters and CA 19-9 levels. METHODS: Based on 426 patients with LAPC who received concurrent CRT between 2004 and 2015, we investigated significant prognostic factors for survival to build a nomogram, including the maximum standardized uptake value (SUVmax) and CA 19-9 levels. Predictive accuracy and discriminative ability were then measured. RESULTS: Median progression-free survival and overall survival (OS) were 9.4 and 15.4 months, respectively, at a median 15-month follow-up. High-dose radiation (EQD2, ≥61 Gy), initial SUVmax <3.5 and CA 19-9 ≤400 U/mL, and surgical resection after CRT were significantly related to prolonged OS by multivariate analysis (p < 0.05). A nomogram model for OS was established and showed good calibration and acceptable discrimination (c-index 0.656). Using the nomogram, 3 different prognosis groups could be identified with a median OS of 25, 15, and 11 months (p < 0.001). CONCLUSION: A nomogram was developed with high-dose radiation (EQD2, ≥61 Gy), initial SUVmax <3.5, CA 19-9 ≤400 U/mL, and surgical resection after CRT for patients with LAPC. This will help in clinical decision-making and in selecting patients for CRT.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Scientific Publishers-
dc.relation.isPartOfRADIOTHERAPY AND ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA nomogram for predicting survival of patients with locally advanced pancreatic cancer treated with chemoradiotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSeo Hee Choi-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.1016/j.radonc.2018.08.006-
dc.contributor.localIdA01551-
dc.contributor.localIdA01956-
dc.contributor.localIdA01956-
dc.contributor.localIdA04867-
dc.contributor.localIdA04867-
dc.relation.journalcodeJ02597-
dc.identifier.eissn1879-0887-
dc.identifier.pmid30177371-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0167814018334443-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.affiliatedAuthor박승우-
dc.contributor.affiliatedAuthor성진실-
dc.contributor.affiliatedAuthor성진실-
dc.contributor.affiliatedAuthor최서희-
dc.contributor.affiliatedAuthor최서희-
dc.citation.volume129-
dc.citation.number2-
dc.citation.startPage340-
dc.citation.endPage346-
dc.identifier.bibliographicCitationRADIOTHERAPY AND ONCOLOGY, Vol.129(2) : 340-346, 2018-
dc.identifier.rimsid57960-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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