Cited 6 times in
Differential Expression of Cancer-Associated Fibroblast-Related Proteins in Ductal Carcinoma in situ According to Molecular Subtype and Stromal Histology
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구자승 | - |
dc.contributor.author | 김혜민 | - |
dc.contributor.author | 이지희 | - |
dc.date.accessioned | 2019-01-15T16:51:24Z | - |
dc.date.available | 2019-01-15T16:51:24Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1015-2008 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166684 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study is to investigate the expression of cancer-associated fibroblast (CAF)-related proteins and their implication in ductal carcinoma in situ (DCIS). METHODS: We constructed a tissue microarray of 223 cases of DCIS and examined immunohistochemical staining for the 7 CAF-related proteins. We classified DCIS into luminal type, human epidermal growth factor receptor-2 (HER-2) type, and triple negative breast cancer (TNBC) according to the immunohistochemical results for estrogen receptor, progesterone receptor, and HER-2. We also classified DCIS into desmoplastic, normal-like, and inflammatory type according to stromal histology. RESULTS: There were significant differences in the expression of S100A4, podoplanin, prolyl 4-hydroxylase subunit alpha 3, NG2, and PDGFRα in stromal cells of DCIS when classified according to molecular subtype. The expression rate of all CAF-related proteins in stromal cells was higher in the HER-2 type and TNBC than in the luminal type (p < 0.001). When classified according to stromal subtype, there were significant differences in the expression of all CAF-related proteins in stromal cells, with the inflammatory stromal type showing higher expression of CAF-related proteins than other stromal types. CONCLUSION: The expression of CAF-related proteins in stromal cells of DCIS varies according to molecular subtype and stromal type. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | S. Karger | - |
dc.relation.isPartOf | PATHOBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Cancer-Associated Fibroblasts/metabolism* | - |
dc.subject.MESH | Cancer-Associated Fibroblasts/pathology | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/diagnosis | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/metabolism | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/pathology* | - |
dc.subject.MESH | Carcinoma, Intraductal, Noninfiltrating/metabolism* | - |
dc.subject.MESH | Carcinoma, Intraductal, Noninfiltrating/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Receptor, ErbB-2/metabolism | - |
dc.subject.MESH | Receptors, Estrogen/metabolism | - |
dc.subject.MESH | Receptors, Progesterone/genetics | - |
dc.subject.MESH | Receptors, Progesterone/metabolism | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/genetics | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/pathology | - |
dc.title | Differential Expression of Cancer-Associated Fibroblast-Related Proteins in Ductal Carcinoma in situ According to Molecular Subtype and Stromal Histology | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Lee J.H. | - |
dc.contributor.googleauthor | Kim H.M. | - |
dc.contributor.googleauthor | Koo J.S. | - |
dc.identifier.doi | 10.1159/000492392 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04553 | - |
dc.contributor.localId | A05169 | - |
dc.relation.journalcode | J02470 | - |
dc.identifier.eissn | 1423-0291 | - |
dc.identifier.pmid | 30223270 | - |
dc.identifier.url | https://www.karger.com/Article/Abstract/492392 | - |
dc.subject.keyword | Breast | - |
dc.subject.keyword | Cancer-associated fibroblast | - |
dc.subject.keyword | Ductal carcinoma in situ | - |
dc.subject.keyword | Stroma | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 김혜민 | - |
dc.contributor.affiliatedAuthor | 이지희 | - |
dc.citation.volume | 85 | - |
dc.citation.number | 5~6 | - |
dc.citation.startPage | 311 | - |
dc.citation.endPage | 321 | - |
dc.identifier.bibliographicCitation | PATHOBIOLOGY, Vol.85(5~6) : 311-321, 2018 | - |
dc.identifier.rimsid | 57953 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.