뇌섬엽 피질의 통증 정보 처리 및 통증 조절 작용

Abstract

Pain is recognized through complex mechanisms and various interactions. Previous research had attempted to identify processes involving pain through animal experiments at molecular levels. However, these studies were unable to specify complex pain conditioning and information processes. To understand the various aspects of such pain processes, it is essential to study other cerebral regions that govern pain signals. In this review, we discussed previous studies to propose that the IC is involved in utilizing pain networks and connect with other areas of the brain. For research accuracy and efficacy regarding the functional significance of this cortical network, neuroimaging and electrophysiological methods are recommended. Also, we provided known molecular mechanisms underlying the changes of the pain modulation system to pain states in the IC. These studies suggest that the IC may be actively involved in the modulation and perception of pain. Our study may provide advisory contents for additional studies to aid researches in the quest for effective methods in modulating pain.