Cited 20 times in
Adipokines as therapeutic targets in breast cancer treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구자승 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2019-01-15T16:48:01Z | - |
dc.date.available | 2019-01-15T16:48:01Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1472-8222 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166648 | - |
dc.description.abstract | Adipocytes, which represent a substantial part of the tumor microenvironment in breast cancer, secrete several adipokines that affect tumorigenesis, cancer progression, metastasis, and treatment resistance via multiple signaling pathways. Areas covered: In this review, we focus on the role of leptin, adiponectin, autotaxin, and interleukin-6 in breast cancer initiation, progression, metastasis, and drug response. Furthermore, we investigated adipokines as potential targets of breast cancer-specific drugs. Expert opinion: Adipokines and adipokine receptors are deregulated in breast cancer. Adipokines play various roles in breast cancer initiation, progression, metastasis, and drug response, hence, adipokine signaling could be an effective drug target. Several clinical trials are in progress to test the efficacy of adipokine targeting agents. However, adipokines also affect metabolic homeostasis; hence, the adverse effects of the targeted drug should be investigated and addressed. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | EXPERT OPINION ON THERAPEUTIC TARGETS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Adipokines as therapeutic targets in breast cancer treatment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1080/14728222.2018.1538356 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J02865 | - |
dc.identifier.eissn | 1744-7631 | - |
dc.identifier.pmid | 30332900 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/14728222.2018.1538356 | - |
dc.subject.keyword | Adipokines | - |
dc.subject.keyword | adiponectin | - |
dc.subject.keyword | autotaxin | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | interleukin-6 | - |
dc.subject.keyword | leptin | - |
dc.subject.keyword | target therapy | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 941 | - |
dc.citation.endPage | 953 | - |
dc.identifier.bibliographicCitation | EXPERT OPINION ON THERAPEUTIC TARGETS, Vol.22(11) : 941-953, 2018 | - |
dc.identifier.rimsid | 57920 | - |
dc.type.rims | ART | - |
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