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Adipokines as therapeutic targets in breast cancer treatment

Authors
 Yoon Jin Cha  ;  Ja Seung Koo 
Citation
 EXPERT OPINION ON THERAPEUTIC TARGETS, Vol.22(11) : 941-953, 2018 
Journal Title
 EXPERT OPINION ON THERAPEUTIC TARGETS 
ISSN
 1472-8222 
Issue Date
2018
Keywords
Adipokines ; adiponectin ; autotaxin ; breast cancer ; interleukin-6 ; leptin ; target therapy
Abstract
Adipocytes, which represent a substantial part of the tumor microenvironment in breast cancer, secrete several adipokines that affect tumorigenesis, cancer progression, metastasis, and treatment resistance via multiple signaling pathways. Areas covered: In this review, we focus on the role of leptin, adiponectin, autotaxin, and interleukin-6 in breast cancer initiation, progression, metastasis, and drug response. Furthermore, we investigated adipokines as potential targets of breast cancer-specific drugs. Expert opinion: Adipokines and adipokine receptors are deregulated in breast cancer. Adipokines play various roles in breast cancer initiation, progression, metastasis, and drug response, hence, adipokine signaling could be an effective drug target. Several clinical trials are in progress to test the efficacy of adipokine targeting agents. However, adipokines also affect metabolic homeostasis; hence, the adverse effects of the targeted drug should be investigated and addressed.
Full Text
https://www.tandfonline.com/doi/full/10.1080/14728222.2018.1538356
DOI
10.1080/14728222.2018.1538356
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166648
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