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A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder: 2-year follow-up

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dc.contributor.author김세주-
dc.contributor.author김찬형-
dc.contributor.author노대영-
dc.contributor.author장원석-
dc.contributor.author장진우-
dc.contributor.author정현호-
dc.date.accessioned2019-01-15T16:46:29Z-
dc.date.available2019-01-15T16:46:29Z-
dc.date.issued2018-
dc.identifier.issn1180-4882-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166632-
dc.description.abstractBACKGROUND: Recently, a new thermal lesioning approach using magnetic resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this approach for treatment-refractory obsessive-compulsive disorder (OCD), and follow-up was short-term. We investigated the efficacy and safety of bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS in patients with treatment-refractory OCD and followed them for 2 years. METHODS: Eleven patients with treatment-refractory OCD were included in the study. Clinical outcomes were evaluated using the Yale-Brown Obsessive Compulsive Scale, the Clinical Global Impression scale (including improvement and severity), the Hamilton Rating Scale for Depression (HAM-D) and the Hamilton Rating Scale for Anxiety (HAM-A) at 1 week and 1, 3, 6, 12 and 24 months following MRgFUS. Neuropsychological functioning, Global Assessment of Functioning and adverse events were also assessed. RESULTS: After MRgFUS, Yale-Brown Obsessive Compulsive Scale scores decreased significantly across the 24-month follow-up period (mean ± standard deviation, 34.4 ± 2.3 at baseline v. 21.3 ± 6.2 at 24 months, p < 0.001). Scores on the Hamilton rating scales for depression and anxiety also significantly decreased from baseline to 24 months (HAM-D, 19.0 ± 5.3 v. 7.6 ± 5.3, p < 0.001; HAM-A, 22.4 ± 5.9 v. 7.9 ± 3.9, p < 0.001). Global Assessment of Functioning scores improved significantly (35.8 ± 4.9 at baseline v. 56.0 ± 10.3 at 24 months, p < 0.001) and Memory Quotient significantly improved, but other neuropsychological functions were unchanged. The side effects of MRgFUS included headache and vestibular symptoms, but these were mild and transient. LIMITATIONS: The main limitations of this study were the small sample size and the open-label design. CONCLUSION: Bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS may improve obsessive-compulsive, depressive and anxiety symptoms in patients with treatment-refractory OCD, without serious adverse effects.-
dc.description.statementOfResponsibilityopen-
dc.languageCanada-
dc.publisher1488-2434-
dc.relation.isPartOfJOURNAL OF PSYCHIATRY & NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder: 2-year follow-up-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.googleauthorSe Joo Kim-
dc.contributor.googleauthorDaeyoung Roh-
dc.contributor.googleauthorHyun Ho Jung-
dc.contributor.googleauthorWon Seok Chang-
dc.contributor.googleauthorChan-Hyung Kim-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.1503/jpn.170188-
dc.contributor.localIdA00604-
dc.contributor.localIdA01036-
dc.contributor.localIdA01036-
dc.contributor.localIdA01276-
dc.contributor.localIdA01276-
dc.contributor.localIdA03454-
dc.contributor.localIdA03454-
dc.contributor.localIdA03484-
dc.contributor.localIdA03484-
dc.contributor.localIdA03775-
dc.contributor.localIdA03775-
dc.relation.journalcodeJ03565-
dc.identifier.eissn1488-2434-
dc.identifier.pmid30125241-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.affiliatedAuthor김세주-
dc.contributor.affiliatedAuthor김찬형-
dc.contributor.affiliatedAuthor김찬형-
dc.contributor.affiliatedAuthor노대영-
dc.contributor.affiliatedAuthor노대영-
dc.contributor.affiliatedAuthor장원석-
dc.contributor.affiliatedAuthor장원석-
dc.contributor.affiliatedAuthor장진우-
dc.contributor.affiliatedAuthor장진우-
dc.contributor.affiliatedAuthor정현호-
dc.contributor.affiliatedAuthor정현호-
dc.citation.volume43-
dc.citation.number5-
dc.citation.startPage327-
dc.citation.endPage337-
dc.identifier.bibliographicCitationJOURNAL OF PSYCHIATRY & NEUROSCIENCE, Vol.43(5) : 327-337, 2018-
dc.identifier.rimsid57904-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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