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Prediction Models of Cognitive Trajectories in Patients with Nonamnestic Mild Cognitive Impairment

DC FieldValueLanguage
dc.contributor.author김창수-
dc.date.accessioned2019-01-15T16:43:30Z-
dc.date.available2019-01-15T16:43:30Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166604-
dc.description.abstractTo evaluate prediction models of cognitive trajectories in patients with nonamnestic mild cognitive impairment (naMCI) using group-based trajectory analysis, we evaluated 121 patients with naMCI who underwent at least their first three yearly assessments. Group-based trajectory models were used to classify cognitive trajectories based on Clinical Dementia Rating Sum of Boxes scores over four years in patients with naMCI. A total of 22 patients (18.2%) were classified into the "fast-decliners" group, while 99 patients (81.8%) were classified into the "slow-decliners" group. The mean age was higher in the fast-decliners than in the slow-decliners (p = 0.037). Compared to the slow-decliners, the fast-decliners were more frequently impaired in the domains of language (p = 0.038) and frontal/executive functions (p = 0.042), and had more frequent multiple-domain cognitive impairment (p = 0.006) on baseline neuropsychological tests. The rate of conversion to dementia was significantly higher in the fast-decliners than in the slow-decliners (86.4% vs. 10.1%, p < 0.001). Our findings showed that there are indeed distinct patterns of cognitive trajectories in patients with naMCI. Close observation of naMCI patients' baseline demographic and clinical profiles in clinical settings may help identify individuals at greatest risk for dementia.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrediction Models of Cognitive Trajectories in Patients with Nonamnestic Mild Cognitive Impairment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine and Public Health (예방의학교실)-
dc.contributor.googleauthorJin San Lee-
dc.contributor.googleauthorSeong-Kyung Cho-
dc.contributor.googleauthorHee Jin Kim-
dc.contributor.googleauthorYeo Jin Kim-
dc.contributor.googleauthorKey-Chung Park-
dc.contributor.googleauthorSamuel N. Lockhart-
dc.contributor.googleauthorDuk L. Na-
dc.contributor.googleauthorChangsoo Kim-
dc.contributor.googleauthorSang Won Seo-
dc.identifier.doi10.1038/s41598-018-28881-1-
dc.contributor.localIdA01042-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid29993022-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.affiliatedAuthor김창수-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage10468-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.8(1) : 10468, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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