Cited 18 times in
Characterization of Microbiota in Bronchiectasis Patients with Different Disease Severities
DC Field | Value | Language |
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dc.contributor.author | 이상훈 | - |
dc.date.accessioned | 2019-01-07T16:41:05Z | - |
dc.date.available | 2019-01-07T16:41:05Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166569 | - |
dc.description.abstract | The applications of the 16S rRNA gene pyrosequencing has expanded our knowledge of the respiratory tract microbiome originally obtained using conventional, culture-based methods. In this study, we employed DNA-based molecular techniques for examining the sputum microbiome in bronchiectasis patients, in relation to disease severity. Of the sixty-three study subjects, forty-two had mild and twenty-one had moderate or severe bronchiectasis, which was classified by calculating the FACED score, based on the FEV₁ (forced expiratory volume in 1 s, %) (F, 0⁻2 points), age (A, 0⁻2 points), chronic colonization by Pseudomonas aeruginosa (C, 0⁻1 point), radiographic extension (E, 0⁻1 point), and dyspnoea (D, 0⁻1 point). Bronchiectasis was defined as mild, at 0⁻2 points, moderate at 3⁻4 points, and severe at 5⁻7 points. The mean age was 68.0 ± 9.3 years; thirty-three patients were women. Haemophilus (p = 0.005) and Rothia (p = 0.043) were significantly more abundant in the mild bronchiectasis group, whereas Pseudomonas (p = 0.031) was significantly more abundant in the moderate or severe group. However, in terms of the alpha and beta diversity, the sputum microbiota of the two groups did not significantly differ, i.e., the same dominant genera were found in all samples. Further large-scale studies are needed to investigate the sputum microbiome in bronchiectasis | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Characterization of Microbiota in Bronchiectasis Patients with Different Disease Severities | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sang Hoon Lee | - |
dc.contributor.googleauthor | YeonJoo Lee | - |
dc.contributor.googleauthor | Jong Sun Park | - |
dc.contributor.googleauthor | Young-Jae Cho | - |
dc.contributor.googleauthor | Ho Il Yoon | - |
dc.contributor.googleauthor | Choon-Taek Lee | - |
dc.contributor.googleauthor | Jae Ho Lee | - |
dc.identifier.doi | 10.3390/jcm7110429 | - |
dc.contributor.localId | A02836 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 30423913 | - |
dc.subject.keyword | FACED score | - |
dc.subject.keyword | bronchiectasis | - |
dc.subject.keyword | microbiome | - |
dc.contributor.alternativeName | Lee, Sang Hoon | - |
dc.contributor.affiliatedAuthor | 이상훈 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | E429 | - |
dc.citation.endPage | E438 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.7(11) : E429-E438, 2018 | - |
dc.identifier.rimsid | 58255 | - |
dc.type.rims | ART | - |
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