Cited 14 times in
Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study
DC Field | Value | Language |
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dc.contributor.author | 이상훈 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 김송이 | - |
dc.date.accessioned | 2019-01-07T16:40:58Z | - |
dc.date.available | 2019-01-07T16:40:58Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1465-9921 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166568 | - |
dc.description.abstract | BACKGROUND: The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a multi-center study in Korea. METHODS: The Korean interstitial lung disease (ILD) Study Group surveyed ILD patients from 2003 to 2007. Patients were divided into two groups to compare the treatment response: response group (forced vital capacity (FVC) improves ≥10% after 1 year) and non-response group (FVC <10%). Factors affecting treatment response were evaluated by multivariate logistic regression analysis. RESULTS: A total of 261 patients with iNSIP were enrolled, and 95 patients were followed-up for more than 1 year. Corticosteroid treatment was performed in 86 patients. The treatment group showed a significant improvement in lung function after 1-year: FVC, 10.0%; forced expiratory volume (FEV1), 9.8%; diffusing capacity of the lung for carbon monoxide (DLco), 8.4% (p < 0.001). Sero-negative anti-nuclear antibody (ANA) was significantly related with lung function improvement. Sero-positivity ANA was significantly lower in the response group (p = 0.013), compared to that in the non-response group. A shorter duration of respiratory symptoms at diagnosis was significantly associated with a good response to treatment (p = 0.018). CONCLUSION: Treatment with corticosteroids and/or immunosuppressants improved lung function in iNSIP patients, which was more pronounced in sero-negative ANA and shorter symptom duration patients. These findings suggest that early treatment should be considered in iNSIP patients, even in an early disease stage. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central Ltd | - |
dc.relation.isPartOf | RESPIRATORY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenal Cortex Hormones/administration & dosage | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Idiopathic Interstitial Pneumonias/diagnosis | - |
dc.subject.MESH | Idiopathic Interstitial Pneumonias/drug therapy* | - |
dc.subject.MESH | Idiopathic Interstitial Pneumonias/epidemiology* | - |
dc.subject.MESH | Immunosuppressive Agents/administration & dosage | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sang Hoon Lee | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Song Yee Kim | - |
dc.contributor.googleauthor | Dong Soon Kim | - |
dc.contributor.googleauthor | Young Whan Kim | - |
dc.contributor.googleauthor | Man Pyo Chung | - |
dc.contributor.googleauthor | Soo Taek Uh | - |
dc.contributor.googleauthor | Choon Sik Park | - |
dc.contributor.googleauthor | Sung Woo Park | - |
dc.contributor.googleauthor | Sung Hwan Jeong | - |
dc.contributor.googleauthor | Yong Bum Park | - |
dc.contributor.googleauthor | Hong Lyeol Lee | - |
dc.contributor.googleauthor | Jong Wook Shin | - |
dc.contributor.googleauthor | Eun Joo Lee | - |
dc.contributor.googleauthor | Jin Hwa Lee | - |
dc.contributor.googleauthor | Yangin Jegal | - |
dc.contributor.googleauthor | Hyun Kyung Lee | - |
dc.contributor.googleauthor | Yong Hyun Kim | - |
dc.contributor.googleauthor | Jin Woo Song | - |
dc.contributor.googleauthor | Jong Sun Park | - |
dc.identifier.doi | 10.1186/s12931-017-0686-7 | - |
dc.contributor.localId | A02836 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A00626 | - |
dc.relation.journalcode | J02616 | - |
dc.identifier.eissn | 1465-993X | - |
dc.identifier.pmid | 29212510 | - |
dc.subject.keyword | Non-specific interstitial pneumonia | - |
dc.subject.keyword | Pulmonary lung function | - |
dc.subject.keyword | Treatment | - |
dc.contributor.alternativeName | Lee, Sang Hoon | - |
dc.contributor.affiliatedAuthor | 이상훈 | - |
dc.contributor.affiliatedAuthor | 박무석 | - |
dc.contributor.affiliatedAuthor | 김송이 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 204 | - |
dc.identifier.bibliographicCitation | RESPIRATORY RESEARCH, Vol.18(1) : 204, 2017 | - |
dc.identifier.rimsid | 58254 | - |
dc.type.rims | ART | - |
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