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Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease
DC Field | Value | Language |
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dc.contributor.author | 박경희 | - |
dc.date.accessioned | 2019-01-02T16:45:29Z | - |
dc.date.available | 2019-01-02T16:45:29Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166438 | - |
dc.description | 의학과/박사 | - |
dc.description.abstract | Background: Various allergenic proteins are produced by house dust mites (HDM). However, the allergenicity and clinical implications of theses allergens are unknown. Objective: The purpose of this study was to identify allergens in Dermatophagoides farinae and elucidate the sensitization profiles to these in Korean patients suffering from respiratory (allergic rhinitis and/or asthma) and atopic dermatitis symptoms. Methods: IgE reactivities in sera from 160 HDM allergy patients were analyzed by one- and two-dimensional gel electrophoresis and immunoblotting. IgE-reactive components were identified by liquid chromatography-coupled electrospray ionization–tandem mass spectrometry. Nine recombinant mite allergens (Der f 1, Der f 2, Der f 10, Der f 11, Der f 13, Der f 14, Der f 30, Der f 32, and Der f Alt a 10) were produced, and the IgE reactivity in sera to each was determined by ELISAs. Results: Der f 1 and Der f 2 were recognized by IgE in serum samples from 88.1% and 78.1% of all patients, respectively. Patients with respiratory allergies were mainly sensitized to these major allergens, whereas patients with atopic dermatitis symptoms showed poly-sensitization to major and minor allergen components (including Der f 11, Der f 13, Der f 14, Der f 32, and Der f Alt a 10). Conclusions: Patients with respiratory allergic disease sensitize to major allergen components of HDM. Those with atopic dermatitis were sensitized to a broader range of minor allergen components of HDM (Der f 11, Der f 13, Der f 14, Der f 32, and Der f Alt a 10). | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.publisher | 연세대학교 | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease | - |
dc.title.alternative | 집먼지진드기 알레르기 환자에서 질환 별 집먼지진드기 성분항원 감작패턴 비교 | - |
dc.type | Thesis | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.localId | A01427 | - |
dc.description.degree | 박사 | - |
dc.contributor.alternativeName | Park, Kyung Hee | - |
dc.contributor.affiliatedAuthor | 박경희 | - |
dc.type.local | Dissertation | - |
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