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Synergistic effects of simvastatin and bone marrow-derived mesenchymal stem cells on hepatic fibrosis
DC Field | Value | Language |
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dc.contributor.author | 김성훈 | - |
dc.date.accessioned | 2019-01-02T16:45:19Z | - |
dc.date.available | 2019-01-02T16:45:19Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166430 | - |
dc.description | 의학과 | - |
dc.description.abstract | The beneficial effects of simvastatin on fibrosis in various organs have been reported. In addition, bone marrow (BM)-derived mesenchymal stem cells (MSCs) have been suggested as an effective therapy for hepatic fibrosis and cirrhosis. Recent evidence suggests that pharmacological treatment devoted to regulating stem cell function is a potential new therapeutic strategy that is drawing nearer to clinical practice. The aim of this study was to determine whether the combination treatment of simvastatin plus MSCs (Sim-MSCs) could have a synergistic effect on hepatic fibrosis in a thioacetamide (TAA)-induced cirrhotic rat model and hepatic stellate cells (HSCs). Cirrhotic livers from rats treated with Sim-MSCs exhibited histological improvement compared to those treated with simvastatin alone. Sim-MSCs combination treatment decreased hepatic collagen distribution, lowered the hydroxyproline content, and rescued liver function impairment in rats with TAA-induced cirrhosis. These protective effects were more potent with Sim-MSCs than with simvastatin alone. The upregulation of collagen-1, α-smooth muscle actin (α-SMA), transforming growth factor (TGF)-b1, and phospho-Smad3 in cirrhotic livers was prevented by the administration of Sim-MSCs. Intriguingly, Sim-MSCs inhibited both TGF-b/Smad3 signaling and α-SMA in HSCs. The Sim-MSCs combination treatment exeed strong protective effects against hepatic fibrosis by suppressing TGF-b/Smad signaling. Simvastatin could act synergistically with MSCs as an efficient therapeutic approach for intractable cirrhosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | 연세대학교 | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Synergistic effects of simvastatin and bone marrow-derived mesenchymal stem cells on hepatic fibrosis | - |
dc.title.alternative | 간섬유화에 대한 simvastatin 및 골수 유래 중간엽 줄기세포의 상승효과 | - |
dc.type | Thesis | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.localId | A00597 | - |
dc.description.degree | 박사 | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | 김성훈 | - |
dc.type.local | Dissertation | - |
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