20세 이상의 성인에서 이상지질혈증과 케톤뇨와의 상관관계

Abstract

Background: In various studies, the presence of ketonuria after at least an 8-hr fast is known to be possibly indicative of metabolic superiority. All metabolic parameters (including body weight, waist circumference, fasting glucose level, blood pressure, insulin level, high-density lipoprotein level, and triglyceride level) were more favorable in the ketonuria group than in the non-ketonuria group. In this study, we investigated the association between ketonuria and dyslipidemia. Methods: We analyzed data from the 2013–2015 Korea National Health and Nutrition Examination Survey. Of the 17,780 people who participated in the survey, 9,269 were selected. The relationship of ketonuria with dyslipidemia was assessed using multivariable logistic regression analysis. Results: The prevalence of dyslipidemia in the ketonuria-positive group was statistically significantly lower than that in the non-ketonuria group. Of the study subjects, 11.2% had hypercholesterolemia, 10.1% had hypertriglyceridemia, 22.4% had hypo-high-density lipoprotein cholesterolemia, and 10% had higher-low-density lipoprotein cholesterolemia. Ketonuria was associated with a lower risk of hypertriglyceridemia (odds ratio 0.620, 95% confidence interval 0.430–0.896) and hypo-high-density lipoprotein cholesterolemia (odds ratio 0.714, 95% confidence interval 0.551–0.926), after adjusting for confounding variables. Conclusion: The risk of dyslipidemia was lower in the ketonuria group than in the non-ketonuria group. The presence of ketonuria is associated with the prevalence of dyslipidemia and the development of hypertriglyceridemia and hypo-high-density lipoprotein cholesterolemia.