소아 헤르페스목구멍염 입원 환자의 최근 임상양상: 지난 2년간(2011-2012) 용인지역

Abstract

Purpose: Herpangina is a contagious febrile disorder in children and there had been a few clinical studies in Korea. The purpose of this investigation is to know its recent clinical features. Methods: I collected the informations of herpangina patients retrospectively who had been admitted and diagnosed clinically at the Department of Pediatrics, Yongin Severance Hospital, Yongin, Korea from January 2011 to December 2012. I investigated their clinical characteristics. Results: There were 67 cases for 2 years(32 boys and 35 girls). The mean age was 1.6 ± 1.5 years old. Fifty-six cases(83.6%) were younger than 3 years old and peak age was 1 year old. The most frequent month was June(28.3%). Clinical features were fever(97.0%), poor oral intake(91.0%), sore throat(43.3%), cough(38.3%), sputum(38.3%), rhinorrhea(25.4%), vomiting(13.4%). There were 17 cases of pneumonia(25.4%), 4 gastroenteritis(6.0%), 2 croup(3.0%), 2 bronchiolitis(3.0%), 2 febrile convulsion(3.0%). Serum aspartate transaminase and alanine transaminase levels were elevated in 34 cases(50.7%) and 4 cases(6.0%) respectively. Serum bicarbonate concentration was decreased in 41 cases(61.2%). Serum C-reactive protein, erythrocyte sedimentation rate, peripheral blood leukocyte count, urinary ketone were increased in 57 cases(85.1%), 51 cases(76.1%), 22 cases(32.8%), 9 cases(13.4%) respectively. The serum bicarbonate concentration in 2011 was lower than that in 2012(18.0 ± 2.4 mmole/L versus 20.0 ± 2.6 mmole/L; P = 0.005) and blood platelet count in 2011 were higher than that in 2012(295,342.1 ± 94,827.7/μL versus 249,511.7 ± 61,289.5/μL ; P = 0.028). Conclusion: Because the proportion of herpangina patients with various organ involvements has been notable, it should not be confined as a localized disorder any longer. As their clinical manifestations of 2011 and 2012 were not comparable, continuous monitoring and study for it should be carried on.