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저산소성 허혈성 뇌손상 신생백서에서 21-aminosteroid U74389G 투여가 뇌손상 및 뇌부종에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 박국인 | - |
dc.date.accessioned | 2018-12-28T02:05:00Z | - |
dc.date.available | 2018-12-28T02:05:00Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1226-1513 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166242 | - |
dc.description.abstract | PURPOSE To investigate the effect of 21-aminosteroid U74389G (U) on the extent of brain damage and edema formation in the newborn rats with hypoxic ischemic (HI) brain injury. METHODS This is a randomized, placebo-controlled, experimental study. The subjects were 113 seven-days-old rats with HI injury. Pups were treated with 3, 10, or 20 mg/ kg of U intraperitoneally 30 minutes before hypoxia (Group 1, 2, 3: n=10, 13, 11), 10 mg/kg of U immediately after hypoxia (n=11) (Group 4), 10 mg/kg of U 30 minutes before and after hypoxia (n=n=13) (Group 5), or vehicle (n=12) (Group C). We expressed the degree of brain infarction and brain edema in % atrophy (Left hemisphere-Right hemisphere/Left hemispherex100) and water content % (wet weight-dry weight/wet weightx100) RESULTS: There were significant reductions in the diameters of right hemisphere compared with those of left hemisphere in vehicle and U treated animals (P<0.05). As to the cortical thickness, group 2, 3 and 5 pups showed no significant reductions in the right side compared with the left side implicating that U treatment in these groups was of benefit in attenuating HI cortical injury, while there was significant difference between the right and left side in group 1, 4 and C animals (P<0.001). There was a significant difference (P< 0.01) in % atrophy of group 2, 3, 5 versus group C, but the mean % atrophy was similar in groups 1, 4 and C. There was a significant (P<0.05) increase of water content in right hemisphere compared with left hemisphere both in U and vehicle treated groups. CONCLUSION Pre-treatment and prepost-treatment at moderate doses (10 or more mg/kg) of 21-aminosteroid U74389G reduced the extent of perinatal hypoxic-ischemic brain damages, especially in the cortex, but do not affect the extent of brain edema. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Journal of the Korean Society of Neonatology | - |
dc.publisher | Journal of the Korean Society of Neonatology | - |
dc.relation.isPartOf | Journal of the Korean Society of Neonatology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 저산소성 허혈성 뇌손상 신생백서에서 21-aminosteroid U74389G 투여가 뇌손상 및 뇌부종에 미치는 영향 | - |
dc.title.alternative | Effect of 21-aminosteroid U74389G on the Extent of Brain Damage and Edema in the Newborn Rats with Hypoxic-ischemic Injury | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | 이미선 | - |
dc.contributor.googleauthor | 박문성 | - |
dc.contributor.googleauthor | 박국인 | - |
dc.contributor.googleauthor | 이철 | - |
dc.contributor.googleauthor | 한동관 | - |
dc.contributor.localId | A01438 | - |
dc.relation.journalcode | J01883 | - |
dc.identifier.eissn | 2093-7849 | - |
dc.subject.keyword | 21-aminosteroid U74389G | - |
dc.subject.keyword | Hypoxic-ischemic brain injury | - |
dc.subject.keyword | Perinatal brain damage | - |
dc.subject.keyword | Newborn rat | - |
dc.subject.keyword | Lipid peroxidation | - |
dc.subject.keyword | Oxygen-free radical | - |
dc.subject.keyword | Brain edema | - |
dc.contributor.alternativeName | Park, Kook In | - |
dc.contributor.affiliatedAuthor | 박국인 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 265 | - |
dc.citation.endPage | 271 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Neonatology, Vol.8(2) : 265-271, 2001 | - |
dc.identifier.rimsid | 58246 | - |
dc.type.rims | ART | - |
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