Cited 32 times in
Bruton's tyrosine kinase phosphorylates cAMP-responsive element-binding protein at serine 133 during neuronal differentiation in immortalized hippocampal progenitor cells
DC Field | Value | Language |
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dc.contributor.author | 윤주헌 | - |
dc.date.accessioned | 2018-12-19T16:40:03Z | - |
dc.date.available | 2018-12-19T16:40:03Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166201 | - |
dc.description.abstract | Bruton's tyrosine kinase (BTK) is a member of the Tec family of kinases, which is a subgroup of the nonreceptor cytoplasmic protein tyrosine kinases. BTK has been shown to be important in the proliferation, differentiation, and signal transduction of B cells. Mutations in BTK result in B cell immune deficiency disorders, such as X-linked agammaglobulinemia in humans and X-linked immunodeficiency in mice. Although BTK plays multiple roles in the life of a B cell, its functional role in neuronal cells has not been elucidated. In the present study, we demonstrate that BTK activates transcription factor, cAMP response element (CRE)-binding protein (CREB), and subsequent CRE-mediated gene transcription during basic fibroblast growth factor (bFGF)-induced neuronal differentiation in immortalized hippocampal progenitor cells (H19-7). The kinase activity of BTK is also induced by bFGF, and BTK directly phosphorylates CREB at Ser-133 residue, indicating that BTK has a dual protein kinase activity. In addition, blockading BTK activation significantly inhibits CREB phosphorylation as well as the neurite outgrowth induced by bFGF in H19-7 cells. These results suggest that the activation of BTK and the subsequent phosphorylation of CREB at Ser-133 are important in the neuronal differentiation of hippocampal progenitor cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | American Society for Biochemistry and Molecular Biology | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Agammaglobulinaemia Tyrosine Kinase | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cyclic AMP Response Element-Binding Protein/metabolism* | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Epidermal Growth Factor/pharmacology | - |
dc.subject.MESH | Fibroblast Growth Factor 2/pharmacology | - |
dc.subject.MESH | Hippocampus/cytology | - |
dc.subject.MESH | Hippocampus/metabolism* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/physiology | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Protein-Tyrosine Kinases/metabolism* | - |
dc.subject.MESH | RNA, Small Interfering/physiology | - |
dc.subject.MESH | Response Elements | - |
dc.subject.MESH | Serine/metabolism* | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Stem Cells/metabolism* | - |
dc.title | Bruton's tyrosine kinase phosphorylates cAMP-responsive element-binding protein at serine 133 during neuronal differentiation in immortalized hippocampal progenitor cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Eun Jin Yang | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Kwang Chul Chung | - |
dc.identifier.doi | 10.1074/jbc.M308722200 | - |
dc.contributor.localId | A02604 | - |
dc.relation.journalcode | J01258 | - |
dc.identifier.eissn | 1083-351X | - |
dc.identifier.pmid | 14597636 | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | 윤주헌 | - |
dc.citation.volume | 279 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1827 | - |
dc.citation.endPage | 1837 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.279(3) : 1827-1837, 2004 | - |
dc.identifier.rimsid | 59318 | - |
dc.type.rims | ART | - |
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