Cited 25 times in
Quantitative measurement of lipid rich plaque by coronary computed tomography angiography: A correlation of histology in sudden cardiac death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상은 | - |
dc.contributor.author | 장혁재 | - |
dc.contributor.author | 박형복 | - |
dc.date.accessioned | 2018-12-14T16:41:00Z | - |
dc.date.available | 2018-12-14T16:41:00Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166150 | - |
dc.description.abstract | BACKGROUND AND AIMS: Recent advancements in coronary computed tomography angiography (CCTA) have allowed for the quantitative measurement of high-risk lipid rich plaque. Determination of the optimal threshold for Hounsfield units (HU) by CCTA for identifying lipid rich plaque remains unknown. We aimed to validate reliable cut-points of HU for quantitative assessment of lipid rich plaque. METHODS: 8 post-mortem sudden coronary death hearts were evaluated with CCTA and histologic analysis. Quantitative plaque analysis was performed in histopathology images and lipid rich plaque area was defined as intra-plaque necrotic core area. CCTA images were analyzed for quantitative plaque measurement. Low attenuation plaque (LAP) was defined as any pixel < 30, 45, 60, 75, and 90 HU cut-offs within a coronary plaque. The area of LAP was calculated in each cross-section. RESULTS: Among 105 cross-sections, 37 (35.2%) cross-sectional histology images contained lipid rich plaque. Although the highest specificity for identifying lipid rich plaque was shown with <30 HU cut-off (88.2%), sensitivity (e.g. 55.6% for <75 HU, 16.2% for <30 HU) and negative predictive value (e.g. 75.9% for <75 HU, 65.9% for <30 HU) tended to increase with higher HU cut-offs. For quantitative measurement, <75 HU showed the highest correlation coefficient (0.292, p = 0.003) and no significant differences were observed between lipid rich plaque area and LAP area between histology and CT analysis (Histology: 0.34 ± 0.73 mm2, QCT: 0.37 ± 0.71 mm2, p = 0.701). CONCLUSIONS: LAP area by CCTA using a <75 HU cut-off value demonstrated high sensitivity and quantitative agreement with lipid rich plaque area by histology analysis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Quantitative measurement of lipid rich plaque by coronary computed tomography angiography: A correlation of histology in sudden cardiac death | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Donghee Han | - |
dc.contributor.googleauthor | Sho Torii | - |
dc.contributor.googleauthor | Kazuyuki Yahagi | - |
dc.contributor.googleauthor | Fay Y. Lin | - |
dc.contributor.googleauthor | Ji Hyun Lee | - |
dc.contributor.googleauthor | Asim Rizvi | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Mahn-Won Park | - |
dc.contributor.googleauthor | Hadi Mirhedayati Roudsari | - |
dc.contributor.googleauthor | Wijnand J. Stuijfzand | - |
dc.contributor.googleauthor | Lohendran Baskaran | - |
dc.contributor.googleauthor | Bríain ó Hartaigh | - |
dc.contributor.googleauthor | Hyung-bok Park | - |
dc.contributor.googleauthor | Sang-eun Lee | - |
dc.contributor.googleauthor | Zabiullah Ali | - |
dc.contributor.googleauthor | Robert Kutys | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | James P. Earls | - |
dc.contributor.googleauthor | David Fowler | - |
dc.contributor.googleauthor | Renu Virmani | - |
dc.contributor.googleauthor | James K. Min | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2018.05.024 | - |
dc.contributor.localId | A02827 | - |
dc.contributor.localId | A03490 | - |
dc.contributor.localId | A01752 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 29857958 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021915018302673 | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Coronary computed tomography angiography | - |
dc.subject.keyword | Histology | - |
dc.subject.keyword | Lipid rich plaque | - |
dc.subject.keyword | Necrotic core | - |
dc.contributor.alternativeName | Lee, Sang Eun | - |
dc.contributor.affiliatedAuthor | 이상은 | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.contributor.affiliatedAuthor | 박형복 | - |
dc.citation.volume | 275 | - |
dc.citation.startPage | 426 | - |
dc.citation.endPage | 433 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.275 : 426-433, 2018 | - |
dc.identifier.rimsid | 58315 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.