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Quantitative measurement of lipid rich plaque by coronary computed tomography angiography: A correlation of histology in sudden cardiac death

DC FieldValueLanguage
dc.contributor.author이상은-
dc.contributor.author장혁재-
dc.contributor.author박형복-
dc.date.accessioned2018-12-14T16:41:00Z-
dc.date.available2018-12-14T16:41:00Z-
dc.date.issued2018-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166150-
dc.description.abstractBACKGROUND AND AIMS: Recent advancements in coronary computed tomography angiography (CCTA) have allowed for the quantitative measurement of high-risk lipid rich plaque. Determination of the optimal threshold for Hounsfield units (HU) by CCTA for identifying lipid rich plaque remains unknown. We aimed to validate reliable cut-points of HU for quantitative assessment of lipid rich plaque. METHODS: 8 post-mortem sudden coronary death hearts were evaluated with CCTA and histologic analysis. Quantitative plaque analysis was performed in histopathology images and lipid rich plaque area was defined as intra-plaque necrotic core area. CCTA images were analyzed for quantitative plaque measurement. Low attenuation plaque (LAP) was defined as any pixel < 30, 45, 60, 75, and 90 HU cut-offs within a coronary plaque. The area of LAP was calculated in each cross-section. RESULTS: Among 105 cross-sections, 37 (35.2%) cross-sectional histology images contained lipid rich plaque. Although the highest specificity for identifying lipid rich plaque was shown with <30 HU cut-off (88.2%), sensitivity (e.g. 55.6% for <75 HU, 16.2% for <30 HU) and negative predictive value (e.g. 75.9% for <75 HU, 65.9% for <30 HU) tended to increase with higher HU cut-offs. For quantitative measurement, <75 HU showed the highest correlation coefficient (0.292, p = 0.003) and no significant differences were observed between lipid rich plaque area and LAP area between histology and CT analysis (Histology: 0.34 ± 0.73 mm2, QCT: 0.37 ± 0.71 mm2, p = 0.701). CONCLUSIONS: LAP area by CCTA using a <75 HU cut-off value demonstrated high sensitivity and quantitative agreement with lipid rich plaque area by histology analysis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleQuantitative measurement of lipid rich plaque by coronary computed tomography angiography: A correlation of histology in sudden cardiac death-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDonghee Han-
dc.contributor.googleauthorSho Torii-
dc.contributor.googleauthorKazuyuki Yahagi-
dc.contributor.googleauthorFay Y. Lin-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorAsim Rizvi-
dc.contributor.googleauthorHeidi Gransar-
dc.contributor.googleauthorMahn-Won Park-
dc.contributor.googleauthorHadi Mirhedayati Roudsari-
dc.contributor.googleauthorWijnand J. Stuijfzand-
dc.contributor.googleauthorLohendran Baskaran-
dc.contributor.googleauthorBríain ó Hartaigh-
dc.contributor.googleauthorHyung-bok Park-
dc.contributor.googleauthorSang-eun Lee-
dc.contributor.googleauthorZabiullah Ali-
dc.contributor.googleauthorRobert Kutys-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorJames P. Earls-
dc.contributor.googleauthorDavid Fowler-
dc.contributor.googleauthorRenu Virmani-
dc.contributor.googleauthorJames K. Min-
dc.identifier.doi10.1016/j.atherosclerosis.2018.05.024-
dc.contributor.localIdA02827-
dc.contributor.localIdA03490-
dc.contributor.localIdA03490-
dc.contributor.localIdA01752-
dc.contributor.localIdA01752-
dc.relation.journalcodeJ00260-
dc.identifier.eissn1879-1484-
dc.identifier.pmid29857958-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0021915018302673-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordCoronary computed tomography angiography-
dc.subject.keywordHistology-
dc.subject.keywordLipid rich plaque-
dc.subject.keywordNecrotic core-
dc.contributor.alternativeNameLee, Sang Eun-
dc.contributor.affiliatedAuthor이상은-
dc.contributor.affiliatedAuthor장혁재-
dc.contributor.affiliatedAuthor장혁재-
dc.contributor.affiliatedAuthor박형복-
dc.contributor.affiliatedAuthor박형복-
dc.citation.volume275-
dc.citation.startPage426-
dc.citation.endPage433-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, Vol.275 : 426-433, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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