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Comparative study on metabolite level in tissue-specific human mesenchymal stem cells by an ultra-performance liquid chromatography quadrupole time of flight mass spectrometry
DC Field | Value | Language |
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dc.contributor.author | 임재열 | - |
dc.date.accessioned | 2018-12-14T16:40:22Z | - |
dc.date.available | 2018-12-14T16:40:22Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0003-2670 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166144 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) are a promising therapeutic option for cell-based therapy due to their immunomodulatory and regenerative properties. They can be isolated from various adult tissues, including bone marrow, fat, dental tissue, and glandular tissue. Although they share common characteristics, little is known about the biological differences between MSC populations derived from different tissues. In this study, we used MS to compare the endogenous metabolite level in the human MSCs originating from the bone marrow, adipose tissue, periodontal ligaments, and salivary glands. Using an optimized metabolomics technique, we verified that human MSCs exhibit differences in the endogenous metabolite level depending on their source material, while the multivariate analysis showed that 5 lysophosphatidylcholines and 3 lysophosphatidylethanolamines can serve as markers for the discrimination between MSC sources and may be related to differences in their differentiation capacity. These results may significantly contribute to further mechanistic studies on the MSCs and provide novel insights into the properties and optimal usage of MSCs from different tissues. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | ANALYTICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipose Tissue/cytology | - |
dc.subject.MESH | Adipose Tissue/immunology | - |
dc.subject.MESH | Adipose Tissue/metabolism* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers/metabolism | - |
dc.subject.MESH | Bone Marrow Cells/cytology | - |
dc.subject.MESH | Bone Marrow Cells/immunology | - |
dc.subject.MESH | Bone Marrow Cells/metabolism* | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Chromatography, High Pressure Liquid | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunomodulation/immunology | - |
dc.subject.MESH | Lysophosphatidylcholines/metabolism | - |
dc.subject.MESH | Lysophospholipids/metabolism | - |
dc.subject.MESH | Mass Spectrometry | - |
dc.subject.MESH | Mesenchymal Stem Cells/cytology | - |
dc.subject.MESH | Mesenchymal Stem Cells/immunology | - |
dc.subject.MESH | Mesenchymal Stem Cells/metabolism* | - |
dc.subject.MESH | Metabolomics* | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Organ Specificity | - |
dc.subject.MESH | Periodontal Ligament/cytology | - |
dc.subject.MESH | Periodontal Ligament/immunology | - |
dc.subject.MESH | Periodontal Ligament/metabolism* | - |
dc.subject.MESH | Salivary Glands/cytology | - |
dc.subject.MESH | Salivary Glands/immunology | - |
dc.subject.MESH | Salivary Glands/metabolism* | - |
dc.title | Comparative study on metabolite level in tissue-specific human mesenchymal stem cells by an ultra-performance liquid chromatography quadrupole time of flight mass spectrometry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Seul Ji Lee | - |
dc.contributor.googleauthor | TacGhee Yi | - |
dc.contributor.googleauthor | Soo Hyun Ahn | - |
dc.contributor.googleauthor | Dong Kyu Lim | - |
dc.contributor.googleauthor | Si-na Kim | - |
dc.contributor.googleauthor | Hyun-Joo Lee | - |
dc.contributor.googleauthor | Yun-Kyoung Cho | - |
dc.contributor.googleauthor | Jae-Yol Lim | - |
dc.contributor.googleauthor | Jong-Hyuk Sung | - |
dc.contributor.googleauthor | Jeong-Ho Yun | - |
dc.contributor.googleauthor | Johan Lim | - |
dc.contributor.googleauthor | Sun U. Song | - |
dc.contributor.googleauthor | Sung Won Kwon | - |
dc.identifier.doi | 10.1016/j.aca.2018.04.018 | - |
dc.contributor.localId | A03396 | - |
dc.relation.journalcode | J00131 | - |
dc.identifier.eissn | 1873-4324 | - |
dc.identifier.pmid | 29776537 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S000326701830494X | - |
dc.subject.keyword | Adipose-derived stem cell | - |
dc.subject.keyword | Bone marrow-derived stem cell | - |
dc.subject.keyword | Differentiation | - |
dc.subject.keyword | Mesenchymal stem cell | - |
dc.subject.keyword | Periodontal ligament-derived stem cell | - |
dc.subject.keyword | Salivary gland-derived stem cell | - |
dc.contributor.alternativeName | Lim, Jae Yol | - |
dc.contributor.affiliatedAuthor | 임재열 | - |
dc.citation.volume | 1024 | - |
dc.citation.startPage | 112 | - |
dc.citation.endPage | 122 | - |
dc.identifier.bibliographicCitation | ANALYTICA CHIMICA ACTA, Vol.1024 : 112-122, 2018 | - |
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