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T cell senescence and cardiovascular diseases

Authors
 Hee Tae Yu  ;  Sungha Park  ;  Eui-Cheol Shin  ;  Won-Woo Lee 
Citation
 CLINICAL AND EXPERIMENTAL MEDICINE, Vol.16(3) : 257-263, 2016 
Journal Title
 CLINICAL AND EXPERIMENTAL MEDICINE 
ISSN
 1591-8890 
Issue Date
2016
MeSH
Age Factors ; Aging* ; Cardiovascular Diseases/epidemiology* ; Cardiovascular Diseases/pathology* ; Cytokines/secretion ; Humans ; T-Lymphocytes/immunology*
Keywords
Cardiovascular disease (CVD) ; Cytomegalovirus (CMV) ; Immunosenescence ; Inflammaging
Abstract
Age-related changes in the immune system, commonly termed "immunosenescence," contribute to deterioration of the immune response and fundamentally impact the health and survival of elderly individuals. Immunosenescence affects both the innate and adaptive immune systems; however, the most notable changes are in T cell immunity and include thymic involution, the collapse of T cell receptor (TCR) diversity, an imbalance in T cell populations, and the clonal expansion of senescent T cells. Senescent T cells have the ability to produce large quantities of proinflammatory cytokines and cytotoxic mediators; thus, they have been implicated in the pathogenesis of many chronic inflammatory diseases. Recently, an increasing body of evidence has suggested that senescent T cells also have pathogenic potential in cardiovascular diseases, such as hypertension, atherosclerosis, and myocardial infarction, underscoring the detrimental roles of these cells in various chronic inflammatory responses. Given that cardiovascular disease is the number one cause of death worldwide, there is great interest in understanding the contribution of age-related immunological changes to its pathogenesis. In this review, we discuss general features of age-related alterations in T cell immunity and the possible roles of senescent T cells in the pathogenesis of cardiovascular disease.
Full Text
https://link.springer.com/article/10.1007%2Fs10238-015-0376-z
DOI
10.1007/s10238-015-0376-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Yu, Hee Tae(유희태) ORCID logo https://orcid.org/0000-0002-6835-4759
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166084
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