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Treatment outcomes of 17 patients with atypical spinal meningioma, including 4 with metastases: a retrospective observational study

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dc.contributor.author구성욱-
dc.contributor.author김경현-
dc.contributor.author신동아-
dc.contributor.author박정윤-
dc.contributor.author이성-
dc.contributor.author김긍년-
dc.contributor.author진동규-
dc.contributor.author김근수-
dc.contributor.author윤도흠-
dc.contributor.author조용은-
dc.contributor.author노성현-
dc.date.accessioned2018-12-06T16:41:16Z-
dc.date.available2018-12-06T16:41:16Z-
dc.date.issued2019-
dc.identifier.issn1529-9430-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166058-
dc.description.abstractBACKGROUND CONTEXT: Because of the scarcity of atypical spinal meningioma, there is a lack of research on this type of tumor or its associated metastases. PURPOSE: The aim of this study was to investigate the biological behavior of atypical spinal meningioma and identify its prognostic factors by reviewing surgical and clinical outcomes of patients with these tumors. STUDY DESIGN: A retrospective chart review was performed. PATIENT SAMPLE: We retrospectively reviewed the data from all patients who underwent spinal cord tumor excision between 1994 and 2017. Seventeen patients were pathologically proven to have atypical spinal meningioma. OUTCOME MEASURES: We examined patients' neurologic status by determining their Nurick scores before and after surgery. Moreover, imaging studies, laboratory data, and the employed surgical method were analyzed retrospectively, as was the Ki-67 index and prognosis following postoperative radiation therapy. METHODS: The ranges, locations, and pathologic diagnoses of the tumors were extracted from the radiological and pathological records of each patient. The extent of surgery and progression of disease were confirmed using postoperative enhanced magnetic resonance imaging. Patients were divided into two atypical spinal meningioma groups: primary and metastatic. The demographics, age, sex, presenting symptom duration, tumor location, Simpson resection grade, Ki-67, radiotherapy, recurrence, overall survival, and progression-free survival of patients in both groups were compared. RESULTS: Seventeen patients were included in the analysis, of whom 12 (70%), 4 (24%), and 1 (6%) had tumors in the thoracic, cervical, and sacral regions, respectively. Complete and subtotal resections were achieved in 15 (88%) and 2 (12%) patients, respectively. Overall and progression-free survival rates in patients who underwent complete resection were longer than those in patients who underwent subtotal resection (p<.001). Four patients (24%) had metastatic meningiomas in the brain, among whom three were administered adjuvant radiotherapy after surgery. Two patients with intramedullary atypical spinal meningioma had metastatic tumors and experienced poorer prognoses. The 5-year overall and progression-free survival rates were 84.4% and 85.2%, respectively. The Simpson resection grade, Ki-67 index, and preoperative neurologic status were found to be important prognostic factors on univariate Cox regression analysis (p<.05). CONCLUSIONS: Complete resection should be considered as a primary treatment modality for individuals with atypical spinal meningioma. If subtotal resection is performed, adjuvant therapy can be administered.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Inc.-
dc.relation.isPartOfSpine Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTreatment outcomes of 17 patients with atypical spinal meningioma, including 4 with metastases: a retrospective observational study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorSung Hyun Noh-
dc.contributor.googleauthorKyung Hyun Kim-
dc.contributor.googleauthorDong Ah Shin-
dc.contributor.googleauthorJeong Yoon Park-
dc.contributor.googleauthorSeong Yi-
dc.contributor.googleauthorSung Uk Kuh-
dc.contributor.googleauthorKeung Nyun Kim-
dc.contributor.googleauthorDong Kyu Chin-
dc.contributor.googleauthorKeun Su Kim-
dc.contributor.googleauthorDo Heum Yoon-
dc.contributor.googleauthorYong Eun Cho-
dc.identifier.doi10.1016/j.spinee.2018.06.006-
dc.contributor.localIdA00196-
dc.contributor.localIdA00308-
dc.contributor.localIdA00308-
dc.contributor.localIdA02092-
dc.contributor.localIdA02092-
dc.contributor.localIdA01650-
dc.contributor.localIdA01650-
dc.contributor.localIdA02864-
dc.contributor.localIdA02864-
dc.contributor.localIdA00331-
dc.contributor.localIdA00331-
dc.contributor.localIdA03979-
dc.contributor.localIdA03979-
dc.contributor.localIdA00330-
dc.contributor.localIdA00330-
dc.contributor.localIdA02546-
dc.contributor.localIdA02546-
dc.contributor.localIdA03865-
dc.contributor.localIdA03865-
dc.relation.journalcodeJ02675-
dc.identifier.eissn1878-1632-
dc.identifier.pmid29906618-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1529943018302845-
dc.subject.keywordAdjuvant therapy-
dc.subject.keywordAtypical meningioma-
dc.subject.keywordAtypical spinal meningioma-
dc.subject.keywordComplete resection-
dc.subject.keywordMetastasis-
dc.subject.keywordSpinal cord-
dc.contributor.alternativeNameKuh, Sung Uk-
dc.contributor.affiliatedAuthor구성욱-
dc.contributor.affiliatedAuthor김경현-
dc.contributor.affiliatedAuthor김경현-
dc.contributor.affiliatedAuthor신동아-
dc.contributor.affiliatedAuthor신동아-
dc.contributor.affiliatedAuthor박정윤-
dc.contributor.affiliatedAuthor박정윤-
dc.contributor.affiliatedAuthor이성-
dc.contributor.affiliatedAuthor이성-
dc.contributor.affiliatedAuthor김긍년-
dc.contributor.affiliatedAuthor김긍년-
dc.contributor.affiliatedAuthor진동규-
dc.contributor.affiliatedAuthor진동규-
dc.contributor.affiliatedAuthor김근수-
dc.contributor.affiliatedAuthor김근수-
dc.contributor.affiliatedAuthor윤도흠-
dc.contributor.affiliatedAuthor윤도흠-
dc.contributor.affiliatedAuthor조용은-
dc.contributor.affiliatedAuthor조용은-
dc.citation.volume19-
dc.citation.number2-
dc.citation.startPage276-
dc.citation.endPage284-
dc.identifier.bibliographicCitationSpine Journal, Vol.19(2) : 276-284, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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