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Aromatase inhibitor use is a risk factor of carotid plaque presence in endocrine-responsive breast cancer patients

Authors
 Da Hea Seo  ;  Yongin Cho  ;  Sujin Lee  ;  Seho Park  ;  Seung-Il Kim  ;  Byeong Woo Park  ;  Yumie Rhee 
Citation
 Korean Journal of Internal Medicine : epub., 2017 
Journal Title
 Korean Journal of Internal Medicine 
ISSN
 1226-3303 
Issue Date
2017
Keywords
Aromatase inhibitors ; Breast neoplasms ; Cardiovascular diseases ; Carotid plaque ; Dyslipidemias
Abstract
Background/Aims: The aromatase inhibitors (AIs) are well known anti-hormonal therapy in endocrine-responsive breast cancer patients. It can lead to dyslipidemia and be the risk factor of cardiovascular disease due to low estrogen level. However, some recent studies comparing AIs with placebo have shown controversial results. The aim of this study was to investigate lipid profiles, measurement of carotid intima-media thickness (IMT) and the presence of plaque among endocrine-responsive breast cancer treated with AIs compared to ones that were not treated with AIs. Methods: A total of 85 postmenopausal women, who underwent breast cancer surgery during the age of 50 to 64 without history of statin use were included. There were 42 patients who were treated with AIs over 1 year (group 1) and 43 patients without AIs use (group 2). Serum total cholesterol, high density lipoprotein cholesterol, triglycerides, fasting blood glucose, carotid IMT, and presence of plaque were assessed. Results: The baseline characteristics were similar between two groups and there was no significant difference in carotid IMT irrespective of AIs administration. However, ultrasonographic evaluation of carotid artery revealed that the presence of plaque in AI users was significantly higher than in non-AI users (66.7% vs. 41.9%, p = 0.02; odds ratio, 4.21 in adjusted model; p = 0.01). History of diabetes was also the significant risk factor for the plaque formation. Conclusions: There was no significant difference in lipid profile itself between two groups, but more importantly the presence of the plaque was much higher indicating possible detrimental effect of AI on cardiovascular system.
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DOI
10.3904/kjim.2016.205
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김승일(Kim, Seung Il)
박병우(Park, Byeong Woo) ORCID logo https://orcid.org/0000-0003-1353-2607
서다혜(Seo, D.)
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
조용인(Cho, Yong In) ORCID logo https://orcid.org/0000-0002-4645-816X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166051
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