Cited 150 times in
CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations
DC Field | Value | Language |
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dc.contributor.author | 박병우 | - |
dc.date.accessioned | 2018-12-06T16:40:37Z | - |
dc.date.available | 2018-12-06T16:40:37Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0009-9236 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166049 | - |
dc.description.abstract | The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Using strict eligibility requirements (postmenopausal women with estrogen receptor-positive breast cancer, receiving 20 mg/day tamoxifen for 5 years, criterion 1); CYP2D6 poor metabolizer status was associated with poorer invasive disease-free survival (IDFS: hazard ratio = 1.25; 95% confidence interval = 1.06, 1.47; P = 0.009). However, CYP2D6 status was not statistically significant when tamoxifen duration, menopausal status, and annual follow-up were not specified (criterion 2, n = 2,443; P = 0.25) or when no exclusions were applied (criterion 3, n = 4,935; P = 0.38). Although CYP2D6 is a strong predictor of IDFS using strict inclusion criteria, because the results are not robust to inclusion criteria (these were not defined a priori), prospective studies are necessary to fully establish the value of CYP2D6 genotyping in tamoxifen therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | CLINICAL PHARMACOLOGY & THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | MA Province | - |
dc.contributor.googleauthor | MP Goetz | - |
dc.contributor.googleauthor | H Brauch | - |
dc.contributor.googleauthor | DA Flockhart | - |
dc.contributor.googleauthor | JM Hebert | - |
dc.contributor.googleauthor | R Whaley | - |
dc.contributor.googleauthor | VJ Suman | - |
dc.contributor.googleauthor | W Schroth | - |
dc.contributor.googleauthor | S Winter | - |
dc.contributor.googleauthor | H Zembutsu | - |
dc.contributor.googleauthor | T Mushiroda | - |
dc.contributor.googleauthor | WG Newman | - |
dc.contributor.googleauthor | M-TM Lee | - |
dc.contributor.googleauthor | CB Ambrosone | - |
dc.contributor.googleauthor | MW Beckmann | - |
dc.contributor.googleauthor | J-Y Choi | - |
dc.contributor.googleauthor | A-S Dieudonné | - |
dc.contributor.googleauthor | PA Fasching | - |
dc.contributor.googleauthor | R Ferraldeschi | - |
dc.contributor.googleauthor | L Gong | - |
dc.contributor.googleauthor | E Haschke-Becher | - |
dc.contributor.googleauthor | A Howell | - |
dc.contributor.googleauthor | LB Jordan | - |
dc.contributor.googleauthor | U Hamann | - |
dc.contributor.googleauthor | K Kiyotani | - |
dc.contributor.googleauthor | P Krippl | - |
dc.contributor.googleauthor | D Lambrechts | - |
dc.contributor.googleauthor | A Latif | - |
dc.contributor.googleauthor | U Langsenlehner | - |
dc.contributor.googleauthor | W Lorizio | - |
dc.contributor.googleauthor | P Neven | - |
dc.contributor.googleauthor | AT Nguyen | - |
dc.contributor.googleauthor | B-W Park | - |
dc.contributor.googleauthor | CA Purdie | - |
dc.contributor.googleauthor | P Quinlan | - |
dc.contributor.googleauthor | W Renner | - |
dc.contributor.googleauthor | M Schmidt | - |
dc.contributor.googleauthor | M Schwab | - |
dc.contributor.googleauthor | J-G Shin | - |
dc.contributor.googleauthor | JC Stingl | - |
dc.contributor.googleauthor | P Wegman | - |
dc.contributor.googleauthor | S Wingren | - |
dc.contributor.googleauthor | AHB Wu | - |
dc.contributor.googleauthor | E Ziv | - |
dc.contributor.googleauthor | G Zirpoli | - |
dc.contributor.googleauthor | AM Thompson | - |
dc.contributor.googleauthor | VC Jordan | - |
dc.contributor.googleauthor | Y Nakamura | - |
dc.contributor.googleauthor | RB Altman | - |
dc.contributor.googleauthor | MM Ames | - |
dc.contributor.googleauthor | RM Weinshilboum | - |
dc.contributor.googleauthor | M Eichelbaum | - |
dc.contributor.googleauthor | JN Ingle | - |
dc.contributor.googleauthor | TE Klein | - |
dc.contributor.googleauthor | on behalf of the International Tamoxifen Pharmacogenomics Consortium | - |
dc.identifier.doi | 10.1038/clpt.2013.186 | - |
dc.contributor.localId | A01475 | - |
dc.relation.journalcode | J00608 | - |
dc.identifier.eissn | 1532-6535 | - |
dc.identifier.pmid | 24060820 | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | 박병우 | - |
dc.citation.volume | 95 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 216 | - |
dc.citation.endPage | 227 | - |
dc.identifier.bibliographicCitation | CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol.95(2) : 216-227, 2014 | - |
dc.identifier.rimsid | 59278 | - |
dc.type.rims | ART | - |
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