Triglycerides ; High Density Lipoprotein-Cholesterol ; Intraocular Pressure ; South Korea
Abstract
Background: An elevated intraocular pressure (IOP) is shown to be associated with cardiometabolic risk factors such as age, sex, hypertension, diabetes
mellitus, obesity and metabolic syndrome. The triglyceride (TG) to high density lipoprotein cholesterol (HDL-C) ratio has also been demonstrated to
show a strong association with cardiometabolic disease. We aimed to investigate the association between IOP and the TG:HDL-C ratio in Koreans
without glaucoma.
Methods: We performed a cross-sectional study involving 7,244 participants who enrolled in a health examination program at the Gangnam Severance
Hospital in Korea. Patients were divided into 4 equal groups based on the TG/HDL-C ratio and 2 groups based on IOP values with the difference
between groups being 15 mmHg. Multiple logistic regression analysis was used to assess the relationship between a high IOP and the TG/HDL-C
ratio after adjusting for age, sex, and total serum cholesterol values.
Results: A significant relationship was observed between IOP and the TG/HDL-C ratio, and the mean IOP gradually increased in accordance with the
quartile of the TG/HDL-C ratio (P<0.001). Multiple regression analysis showed that a high IOP was significantly associated with the highest quartile of
the TG/HDL-C ratio after adjusting for age, sex, and total serum cholesterol (95% confidence interval, 1.098–1.545; P<0.01).
Conclusion: A high TG/HDL-C ratio was independently associated with an elevated IOP in Koreans without glaucoma.