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Ideal scaffold design for total ear reconstruction using a three-dimensional printing technique

 Bok Ki Jung  ;  Jae Yoon Kim  ;  Young Seok Kim  ;  Tai Suk Roh  ;  Anna Seo  ;  Keun‐Ho Park  ;  Jin‐Hyung Shim  ;  In Sik Yun 
 Journal of Biomedical Materials Research Part B - Applied Biomaterials, Vol.107(4) : 1295-1303, 2019 
Journal Title
 Journal of Biomedical Materials Research Part B - Applied Biomaterials 
Issue Date
3D printing ; auricular cartilage ; auricular reconstruction ; scaffold
Ear reconstruction using three-dimensional (3D) printing technique has been considered as a good substitute for conventional surgery, because it can provide custom-made 3D framework. However, there are difficulties with its application in clinical use. Researchers have reported 3D scaffolds for ear cartilage regeneration, but the designs of the 3D scaffolds were not appropriate to be used in surgery. Hence, we propose the design of an ideal 3D ear scaffold for use in ear reconstruction surgery. Facial computed tomography (CT) images of the unaffected ear were extracted using a "segmentation" procedure. The selected data were converted to a 3D model and mirrored to create a model of the affected side. The design of 3D model was modified to apply to Nagata's two-stage surgery. Based on the 3D reconstructed model, a 3D scaffold was 3D printed using polycaprolactone. The 3D scaffold closely resembled the real cartilage framework used in current operations in terms of ear anatomy. To account for skin thickness, the 3D scaffold was made 4 mm smaller than the real ear. Furthermore, 2 mm pores were included to allow the implantation of diced cartilage to promote regeneration of the cartilage. 3D printing technology can overcome the limitations of previous auricular reconstruction methods. Further studies are required to achieve a functional and stable substitute for auricular cartilage and to extend the clinical use of the 3D-printed construct. Additionally, the ethical and legal issues regarding the transplantation of 3D-printed constructs and cell culture technologies using human stem cells remain to be solved.
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1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Seok(김영석) ORCID logo https://orcid.org/0000-0002-0981-2107
Kim, Jae Yoon(김재윤)
Roh, Tai Suk(노태석) ORCID logo https://orcid.org/0000-0001-8681-159X
Yun, In Sik(윤인식) ORCID logo https://orcid.org/0000-0003-1103-7047
Jung, Bok Ki(정복기) ORCID logo https://orcid.org/0000-0002-4347-560X
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